Anti-Caspase-1 (phospho S376) 抗体 (ab61794)


  • 製品名Anti-Caspase-1 (phospho S376) antibody
    Caspase-1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Caspase-1 (phospho S376)
  • 特異性ab61794 detects endogenous levels of Caspase-1 only when phosphorylated at serine 376.
  • アプリケーション適用あり: ELISA, IHC-P, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide corresponding to Human Caspase-1.
    Database link: P29466

  • ポジティブ・コントロール
    • Human brain tissue and 293 cell extracts.
  • 特記事項

    The amino acid range of this immunogen is aa350-400 of human Caspase-1 with Acc# P29466 ( This antibody binds to the Caspase-1 subunit p10 region. It binds to isoforms alpha, beta, gamma, delta, and epsilon.



Our Abpromise guarantee covers the use of ab61794 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/20000.
IHC-P 1/50 - 1/100.
WB 1/500 - 1/1000. Detects a band of approximately 30 kDa (predicted molecular weight: 45 kDa).


  • 機能Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
  • 組織特異性Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
  • 配列類似性Belongs to the peptidase C14A family.
    Contains 1 CARD domain.
  • 翻訳後修飾The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
  • 細胞内局在Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CASP-1 antibody
    • CASP1 antibody
    • CASP1_HUMAN antibody
    • Caspase 1 antibody
    • Caspase-1 subunit p10 antibody
    • ICE antibody
    • IL-1 beta-converting enzyme antibody
    • IL-1BC antibody
    • IL1 beta converting enzyme antibody
    • IL1B convertase antibody
    • Interleukin 1 beta convertase antibody
    • Interleukin 1B converting enzyme antibody
    • Interleukin-1 beta convertase antibody
    • Interleukin-1 beta-converting enzyme antibody
    • p45 antibody
    see all

Anti-Caspase-1 (phospho S376) antibody 画像

  • All lanes : Anti-Caspase-1 (phospho S376) antibody (ab61794) at 1/500 dilution

    Lane 1 : 293 cell extracts
    Lane 2 : 293 cell extracts with immunising peptide

    Predicted band size : 45 kDa
    Observed band size : 30 kDa (why is the actual band size different from the predicted?)
  • ab61794 at 1:50 - 1:100 dilution staining Caspase-1 in human brain by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.

Anti-Caspase-1 (phospho S376) antibody (ab61794) 使用論文

ab61794 has not yet been referenced specifically in any publications.

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Thank you for your email.

We do not have any experimental data regarding the reactivity of this antibody to the active or inactive form of Caspase 1. By sequence homology this antibody will recognize both the inactive and active forms of Caspa...

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Thank you for contacting Abcam.
Based on the information from UniPort (SwissProt: P29466), there are a number of isoforms of Caspase-1, one of which is about 30kDa. I am not sure which isoforms is expressed in 293 cell extracts.
Although we d...

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