Anti-Caspase-1 抗体 (ab74279)
Key features and details
- Rabbit polyclonal to Caspase-1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
-
製品名
Anti-Caspase-1 antibody
Caspase-1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Caspase-1 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat -
免疫原
Synthetic peptide within Human Caspase-1 aa 200 to the C-terminus. The exact sequence is proprietary.
Database link: P29466 -
ポジティブ・コントロール
- Jurkat cells. Human placenta.
-
特記事項
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading...
-
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab74279の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-P |
1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. |
特記事項 |
---|
IHC-P
1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. |
ターゲット情報
-
機能
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. -
組織特異性
Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. -
配列類似性
Belongs to the peptidase C14A family.
Contains 1 CARD domain. -
翻訳後修飾
The two subunits are derived from the precursor sequence by an autocatalytic mechanism. -
細胞内局在
Cytoplasm. - Information by UniProt
-
参照データベース
- Entrez Gene: 834 Human
- Entrez Gene: 12362 Mouse
- Entrez Gene: 25166 Rat
- Omim: 147678 Human
- SwissProt: P29466 Human
- SwissProt: P29452 Mouse
- SwissProt: P43527 Rat
- Unigene: 2490 Human
see all -
別名
- CASP-1 antibody
- CASP1 antibody
- CASP1_HUMAN antibody
see all
画像
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (9)
ab74279 は 9 報の論文で使用されています。
- Cui LJ et al. Pectic polysaccharides ameliorate the pathology of ulcerative colitis in mice by reducing pyroptosis. Ann Transl Med 10:347 (2022). PubMed: 35434032
- Zhang B et al. Exosomal miR-27b-3p Derived from Hypoxic Cardiac Microvascular Endothelial Cells Alleviates Rat Myocardial Ischemia/Reperfusion Injury through Inhibiting Oxidative Stress-Induced Pyroptosis via Foxo1/GSDMD Signaling. Oxid Med Cell Longev 2022:8215842 (2022). PubMed: 35847592
- Cao H et al. Inhibition of long non-coding RNA HOXA11-AS against neuroinflammation in Parkinson's disease model via targeting miR-124-3p mediated FSTL1/NF-?B axis. Aging (Albany NY) 13:11455-11469 (2021). PubMed: 33839699
- Liu F et al. Maxing Shigan Decoction Mitigates Mycoplasma pneumonia-Induced Pyroptosis in A549 Cells via the NLRP3 Inflammasome. Infect Drug Resist 14:859-867 (2021). PubMed: 33688221
- Zhao J et al. Lipoxin A4 promotes autophagy and inhibits overactivation of macrophage inflammasome activity induced by Pg LPS. J Int Med Res 49:300060520981259 (2021). PubMed: 33528285
- Jiang R et al. Ligustrazine Alleviate Acute Lung Injury Through Suppressing Pyroptosis and Apoptosis of Alveolar Macrophages. Front Pharmacol 12:680512 (2021). PubMed: 34122107
- Yan A et al. Activated protein C overexpression suppresses the pyroptosis of subarachnoid hemorrhage model cells by regulating the NLRP3 inflammasome pathway. Exp Ther Med 22:1391 (2021). PubMed: 34650639
- Gao Y et al. Induction of autophagy protects human dental pulp cells from lipopolysaccharide-induced pyroptotic cell death. Exp Ther Med 19:2202-2210 (2020). PubMed: 32104285
- Polcyn R et al. Enolase inhibition alters metabolic hormones and inflammatory factors to promote neuroprotection in spinal cord injury. Neurochem Int 139:104788 (2020). PubMed: 32650031