製品の概要

  • 製品名Anti-Caspase-1 antibody
    Caspase-1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to Caspase-1
  • アプリケーション適用あり: IHC-P, WBmore details
  • 種交差性
    交差種: Human, Recombinant Fragment
  • 免疫原

    Recombinant fragment corresponding to Human Caspase-1 aa 1-100.
    Sequence:

    MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQR IWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLL


    Database link: P29466

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab54932 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 3 µg/ml.
WB Use a concentration of 1 - 5 µg/ml.

ターゲット情報

  • 機能Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
  • 組織特異性Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
  • 配列類似性Belongs to the peptidase C14A family.
    Contains 1 CARD domain.
  • 翻訳後修飾The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
  • 細胞内局在Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CASP-1 antibody
    • CASP1 antibody
    • CASP1_HUMAN antibody
    • Caspase 1 antibody
    • Caspase-1 subunit p10 antibody
    • ICE antibody
    • IL-1 beta-converting enzyme antibody
    • IL-1BC antibody
    • IL1 beta converting enzyme antibody
    • IL1B convertase antibody
    • Interleukin 1 beta convertase antibody
    • Interleukin 1B converting enzyme antibody
    • Interleukin-1 beta convertase antibody
    • Interleukin-1 beta-converting enzyme antibody
    • p45 antibody
    see all

Anti-Caspase-1 antibody 画像

  • Caspase-1 antibody (ab54932) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human hepatocellular carcinoma.

  • Western blot against tagged recombinant protein immunogen using ab54932 Caspase-1 antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa

Anti-Caspase-1 antibody (ab54932) 使用論文

This product has been referenced in:
  • Chen Y  et al. MicroRNAs 221/222 and genistein-mediated regulation of ARHI tumor suppressor gene in prostate cancer. Cancer Prev Res (Phila) 4:76-86 (2011). WB ; Human . Read more (PubMed: 21071579) »

See 1 Publication for this product

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