製品の概要

  • 製品名Anti-Caspase-1 antibody
    Caspase-1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Caspase-1
  • 特異性ab53175 detects endogenous levels of fragment of activated Caspase-1 resulting from cleavage adjacent to Asp116. Ab53175 also detects the uncleaved form in WB.
  • アプリケーション適用あり: WB, IHC-P, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to Human Caspase-1 (cis ). Cleaved-Asp210.
    Database link: P29466

  • ポジティブ・コントロール
    • IHC-P: Human lung carcinoma tissue. WB: K562 and HepG2 cell lysates treated with adriamycin.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab53175 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000.

25 kDa (cleaved), 45 kDa (pro-peptide)

IHC-P 1/50 - 1/100.
ELISA 1/10000.

ターゲット情報

  • 機能Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
  • 組織特異性Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
  • 配列類似性Belongs to the peptidase C14A family.
    Contains 1 CARD domain.
  • 翻訳後修飾The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
  • 細胞内局在Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CASP-1 antibody
    • CASP1 antibody
    • CASP1_HUMAN antibody
    • Caspase 1 antibody
    • Caspase-1 subunit p10 antibody
    • ICE antibody
    • IL-1 beta-converting enzyme antibody
    • IL-1BC antibody
    • IL1 beta converting enzyme antibody
    • IL1B convertase antibody
    • Interleukin 1 beta convertase antibody
    • Interleukin 1B converting enzyme antibody
    • Interleukin-1 beta convertase antibody
    • Interleukin-1 beta-converting enzyme antibody
    • p45 antibody
    see all

Anti-Caspase-1 antibody 画像

  • ab53175 at 1/50 dilution staining Caspase-1 in human lung carcinoma by Immunohistochemsitry, Paraffin embedded tissue, in the absence or presence of the immunising peptide.

  • All lanes : Anti-Caspase-1 antibody (ab53175)

    Lane 1 : K562 cell lysate treated with adriamycin
    Lane 2 : HepG2 cell lysate treated with adriamycin

Anti-Caspase-1 antibody (ab53175) 使用論文

ab53175 has not yet been referenced specifically in any publications.

Product Wall

That is good news, thanks for the update. If you have any trouble with the IF stain, please contact us. Good luck!

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"