製品の概要

  • 製品名Anti-Cardiac Troponin C antibody [MAC 352]
    Cardiac Troponin C 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [MAC 352] to Cardiac Troponin C
  • 特異性Antibody reacts with Troponin C isoforms F1 and F2 in flight muscle of Lethocerus and Drosophila, and with Troponin C in non-flight muscles.
  • アプリケーション適用あり: ICC/IF, Electron Microscopy, WBmore details
  • 種交差性
    交差種: Drosophila melanogaster, Lethocerus indicus (Waterbug)
  • 免疫原

    Troponin C purified from Lethocerus indicus (Waterbug) flight muscle.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab51106 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF
Electron Microscopy
WB
  • 追加情報Electron Microscopy: Use at an assay dependent dilution.
    ICC/IF: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 17 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
    • 関連疾患Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:611879]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
      Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13) [MIM:613243]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    • 配列類似性Belongs to the troponin C family.
      Contains 4 EF-hand domains.
    • Information by UniProt
    • 別名
      • tnnc1a antibody
      • Cardiac troponin C antibody
      • slow skeletal and cardiac muscles antibody
      • TN-C antibody
      • TNC antibody
      • Tnnc1 antibody
      • TNNC1_HUMAN antibody
      • TNNI3 antibody
      • Troponin C antibody
      • Troponin C slow antibody
      • Troponin C1 slow antibody
      see all

    Anti-Cardiac Troponin C antibody [MAC 352] (ab51106) 使用論文

    This product has been referenced in:
    • Chechenova MB  et al. The Drosophila Z-disc protein Z(210) is an adult muscle isoform of Zasp52, which is required for normal myofibril organization in indirect flight muscles. J Biol Chem 288:3718-26 (2013). WB, IHC-Fr ; Drosophila melanogaster . Read more (PubMed: 23271733) »
    • Agianian B  et al. A troponin switch that regulates muscle contraction by stretch instead of calcium. EMBO J 23:772-9 (2004). Read more (PubMed: 14765112) »

    See all 4 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"