製品の概要

  • 製品名Anti-Cardiac Troponin C antibody
    Cardiac Troponin C 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Cardiac Troponin C
  • 特異性This antibody recognizes cardiac Troponin C. It shows no reactivity with Troponin T.
  • アプリケーション適用あり: ELISA, IHC-Frmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat, Rabbit, Chicken, Cow, Pig, Xenopus laevis, Zebrafish
  • 免疫原

    Synthetic peptide:

    FVLG AEDGCISTKE

    , corresponding to amino acids 27-40 of Human cardiac Troponin C.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab30807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.

ターゲット情報

  • 機能Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
  • 関連疾患Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:611879]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13) [MIM:613243]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • 配列類似性Belongs to the troponin C family.
    Contains 4 EF-hand domains.
  • Information by UniProt
  • 参照データベース
  • 別名
    • tnnc1a antibody
    • Cardiac troponin C antibody
    • slow skeletal and cardiac muscles antibody
    • TN-C antibody
    • TNC antibody
    • Tnnc1 antibody
    • TNNC1_HUMAN antibody
    • TNNI3 antibody
    • Troponin C antibody
    • Troponin C slow antibody
    • Troponin C1 slow antibody
    see all

Anti-Cardiac Troponin C antibody 画像

  • ab30807 staining Cardiac Troponin C in mouse heart tissue sections by Immunohistochemistry (IHC-Fr - frozen sections). Tissue was fixed with acetone, permeabilized with 0.3% Triton in PBS and blocked with 1% BSA + 5% donkey serum for 45 minutes at room temperature. Samples were incubated with primary antibody (1/500 in PBS + 0.3% Triton + 0.1% BSA + 5% donkey serum) for 16 hours at 4°C. An Alexa Fluor® 594-conjugated donkey anti-goat IgG polyclonal (1/300) was used as the secondary antibody.

    Right - goat isotype control.

    See Abreview

Anti-Cardiac Troponin C antibody (ab30807) 使用論文

This product has been referenced in:

See all 2 Publications for this product

Product Wall

Application Immunohistochemistry (Frozen sections)
Blocking step 0.1% BSA and 5% Donkey serum as blocking agent for 45 minute(s) · Concentration: 5% · Temperature: RT°C
Sample Mouse Tissue sections (mouse heart)
Specification mouse heart
Permeabilization Yes - 0.3% Triton PBS
Fixative Acetone
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Abcam user community

Verified customer

投稿 Jan 30 2015

Thanks for your inquiry. Concerning ab30807, Troponin I, Cardiac, aa27-40 (cTnI) Pab Goat x Human: Crossreactivity of this antibody with human skeletal Troponin I is ~0.02% by ELISA. Please let me know if you require further a...

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