Anti-Cardiac Troponin C 抗体 [7B9] (HRP) (ab8286)

製品の概要

  • 製品名Anti-Cardiac Troponin C antibody [7B9] (HRP)
    Cardiac Troponin C 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [7B9] to Cardiac Troponin C (HRP)
  • 標識HRP
  • アプリケーション適用あり: Sandwich ELISA, WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length protein (Human).

  • 特記事項


    Reconizes TnC in binary complex with cTnI, has no cross reaction with cTnT and cTnI.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab8286 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Sandwich ELISA Use at an assay dependent dilution. Can be paired for Sandwich ELISA with Mouse monoclonal [1A2] to Cardiac Troponin C (ab8285). Can be used as Detection antibody.
WB Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.
AP Use at an assay dependent dilution.

ターゲット情報

  • 機能Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
  • 関連疾患Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:611879]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13) [MIM:613243]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • 配列類似性Belongs to the troponin C family.
    Contains 4 EF-hand domains.
  • Information by UniProt
  • 参照データベース
  • 別名
    • tnnc1a antibody
    • Cardiac troponin C antibody
    • slow skeletal and cardiac muscles antibody
    • TN-C antibody
    • TNC antibody
    • Tnnc1 antibody
    • TNNC1_HUMAN antibody
    • TNNI3 antibody
    • Troponin C antibody
    • Troponin C slow antibody
    • Troponin C1 slow antibody
    see all

Anti-Cardiac Troponin C antibody [7B9] (HRP) (ab8286) 使用論文

ab8286 has not yet been referenced specifically in any publications.

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