製品の概要

  • 製品名Anti-CARD4 antibody
    CARD4 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to CARD4
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    KLH conjugated synthetic peptide selected from the C-terminus of Human CARD (NP_006083.1)

  • ポジティブ・コントロール
    • HL-60 cell lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)This antibody is purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab93370 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報ELISA: 1/1000.
    WB: 1/100 - 1/500. Predicted molecular weight: 108 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.
    • 組織特異性Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon.
    • 配列類似性Contains 1 CARD domain.
      Contains 9 LRR (leucine-rich) repeats.
      Contains 1 NACHT domain.
    • 翻訳後修飾Ubiquitinated. 'Lys-48'-linked polyubiquitination by RNF34 promotes proteasomal degradation and thereby negatively regulates NOD1 for instance in NF-kappa-B activition.
    • 細胞内局在Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CARD 4 antibody
      • CARD4 antibody
      • Caspase recruitment domain 4 antibody
      • Caspase recruitment domain containing protein 4 antibody
      • Caspase recruitment domain family member 4 antibody
      • Caspase recruitment domain protein 4 antibody
      • Caspase recruitment domain-containing protein 4 antibody
      • CLR 7.1 antibody
      • CLR7.1 antibody
      • NLR family CARD domain containing 1 antibody
      • NLRC 1 antibody
      • NLRC1 antibody
      • NOD 1 antibody
      • Nod1 antibody
      • NOD1 protein antibody
      • NOD1_HUMAN antibody
      • Nucleotide binding oligomerization domain containing 1 antibody
      • Nucleotide binding oligomerization domain leucine rich repeat and CARD domain containing 1 antibody
      • Nucleotide-binding oligomerization domain-containing protein 1 antibody
      • Protein Nod1 antibody
      see all

    Anti-CARD4 antibody 画像

    • Anti-CARD4 antibody (ab93370) at 1/100 dilution + HL-60 cell lysate at 35 µg

      Predicted band size : 108 kDa

    Anti-CARD4 antibody (ab93370) 使用論文

    ab93370 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab93370.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"