製品の概要

  • 製品名Anti-CARD14 antibody
    CARD14 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to CARD14
  • アプリケーション適用あり: IHC-Fr, WB, Dot blot, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Chimpanzee, Monkey
  • 免疫原

    Synthetic peptide corresponding to the internal portion of Human CARD14.

  • ポジティブ・コントロール
    • Jurkat whole cell lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C.
  • バッファーPreservative: 0.05% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab64366 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr Use a concentration of 2.5 - 20 µg/ml.
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 130 kDa (predicted molecular weight: 113 kDa).
Dot blot Use at an assay dependent concentration.
ELISA Use a concentration of 0.1 - 1 µg/ml.

ターゲット情報

  • 機能Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
  • 組織特異性Expressed in placenta. Also detected in HeLaS3 cell line, but not in the other cancer cell lines tested. Expressed in epidermal keratinocytes.
  • 関連疾患Defects in CARD14 are the cause of susceptibility to psoriasis type 2 (PSORS2) [MIM:602723]. A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
    Defects in CARD14 are the cause of pityriasis rubra pilaris (PRP) [MIM:173200]. A rare, papulosquamous skin disease characterized by the appearance of keratotic follicular papules, well-demarcated salmon-colored erythematous plaques covered with fine powdery scales interspersed with distinct islands of uninvolved skin, and palmoplantar keratoderma. Most cases are sporadic. The rare familial cases show autosomal dominant inheritance with incomplete penetrance and variable expression. Familial PRP usually presents at birth or appears during the first years of life and runs a chronic course. It is characterized by prominent follicular hyperkeratosis, diffuse palmoplantar keratoderma, and erythema.
  • 配列類似性Contains 1 CARD domain.
    Contains 1 guanylate kinase-like domain.
    Contains 1 PDZ (DHR) domain.
  • 細胞内局在Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Bcl10 interacting MAGUK protein 2 antibody
    • Bimp 2 antibody
    • Bimp2 antibody
    • CAR14_HUMAN antibody
    • CARD 14 antibody
    • CARD containing MAGUK 2 protein antibody
    • CARD containing MAGUK protein 2 antibody
    • Card maguk protein 2 antibody
    • CARD-containing MAGUK protein 2 antibody
    • CARD14 antibody
    • Carma 2 antibody
    • Carma2 antibody
    • Caspase recruitment domain containing protein 14 antibody
    • Caspase recruitment domain family member 14 antibody
    • Caspase recruitment domain protein 14 antibody
    • Caspase recruitment domain-containing protein 14 antibody
    • PRP antibody
    • PSORS2 antibody
    • PSS1 antibody
    see all

Anti-CARD14 antibody 画像

  • Anti-CARD14 antibody (ab64366) at 1/200 dilution + Jurkat whole cell lysate at 15 µg

    Predicted band size : 113 kDa
    Observed band size : 130 kDa (why is the actual band size different from the predicted?)
  • ab64366 at 10µg/ml staining CARD14 in Human placenta by Immunohistichemistry (frozen sections).Localization of the antibody can be seen as the precipitated red signal. A hematoxylin purple nuclear counterstain in placental trophoblasts has been used.

Anti-CARD14 antibody (ab64366) 使用論文

ab64366 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us. I was not able to obtain the exact sequence of the immunogen but I did receive a range that contains it: amino acids 410-435 of human CARD14, which is PPGVLKQEARTREPCPREKQRLVRMH I hope this information is helpful...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"