製品の概要

  • 製品名Anti-CARD11 antibody
    CARD11 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to CARD11
  • アプリケーション適用あり: WBmore details
  • 種交差性

    交差が予測される動物種: Mouse, Human
  • 免疫原

    Synthetic peptide: QRKTIWVDEDQL, corresponding to C terminal amino acids 1131-1147 of Human CARD 11.

  • 特記事項GenBank Accession Number – NP_115791. LocusLink ID - 84433 (human). Gene Ontology terms - guanylate kinase activity; protein binding; intracellular signaling cascade; apoptosis; kinesin complex; intracellular; membrane fraction; apoptosis regulator activity; activation of NF-kappaB-inducing kinase.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab4358 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報Peptide ELISA: antibody detection limit dilution 1:32,000.

    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 150 kDa (predicted molecular weight: 133 kDa).

    An additional band of unknown identity was also consistently observed at 60kDa. This band was successfully blocked by incubation with the immunising peptide.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
    • 組織特異性Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLa S3, Molt-4, A549 and G431 cells.
    • 配列類似性Contains 1 CARD domain.
      Contains 1 guanylate kinase-like domain.
      Contains 1 PDZ (DHR) domain.
    • 翻訳後修飾Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCBB leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.
    • 細胞内局在Cytoplasm. Membrane raft. Colocalized with DPP4 in membrane rafts.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 0610008L17Rik antibody
      • 2410011D02Rik antibody
      • Bcl10 interacting maguk protein 3 antibody
      • BIMP 3 antibody
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      • CAR11_HUMAN antibody
      • CARD 11 antibody
      • CARD containing MAGUK protein 3 antibody
      • Card maguk protein 1 antibody
      • CARD-containing MAGUK protein 1 antibody
      • CARD11 antibody
      • CARD11 protein antibody
      • Carma 1 antibody
      • CARMA1 antibody
      • Caspase recruitment domain containing protein 11 antibody
      • Caspase recruitment domain family member 11 antibody
      • Caspase recruitment domain-containing protein 11 antibody
      • MGC133069 antibody
      see all

    Anti-CARD11 antibody 画像

    Anti-CARD11 antibody (ab4358) 使用論文

    ab4358 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab4358.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"