製品の概要

  • 製品名
    Anti-Carboxypeptidase B2 antibody
    Carboxypeptidase B2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Carboxypeptidase B2
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 100 - 200 of Human Carboxypeptidase B2 .

    (Peptide available as ab88171.)

  • ポジティブ・コントロール
    • This antibody gave a positive signal in Human Liver Tissue Lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab78445 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 52 kDa (predicted molecular weight: 48 kDa).

ターゲット情報

  • 関連性
    This protein belongs to a family of Zn-containing metallocarboxypeptidases specific to C-terminal lysine and arginine residues. It circulates in plasma as a zymogen with molecular weight of 55 kDa (401 amino acid residues; pI 5.0). Being activated by thrombin-thrombomodulin complex during blood coagulation, it exerts carboxypeptidase activity. Activated carboxypeptidase B2 removes C-terminal lysine residues from fibrin, which is necessary for plasminogen binding to fibrin. This prevents plasminogen from activation into plasmin and retards the lysis of a fibrin clot. The concentration in plasma of healthy people is 5 – 10 µg/ml. High plasma levels were found in patients with stable angina pectoris and angiographically verified coronary artery disease. Elevated concentration in blood is considered as a risk factor for venous thrombosis. A deficiency might contribute to the severity of bleeding disorders in hemophilias A and B, and decreased levels are found in chronic liver disease.
  • 細胞内局在
    Secreted
  • 参照データベース
  • 別名
    • 1110032P04Rik antibody
    • 4930405E17Rik antibody
    • bA139H14.2 antibody
    • Carboxypeptidase B like protein antibody
    • Carboxypeptidase U antibody
    • CarboxypeptidaseB2 antibody
    • CarboxypeptidaseU antibody
    • CP B2 antibody
    • CPB 2 antibody
    • CPB2 antibody
    • CPU antibody
    • PCPB antibody
    • Plasma carboxypeptidase B antibody
    • Plasma carboxypeptidase B2 antibody
    • Procarboxypeptidase B antibody
    • Procarboxypeptidase R antibody
    • Procarboxypeptidase U antibody
    • TAFI antibody
    • Thrombin activable fibrinolysis inhibitor antibody
    • Thrombin activatable fibrinolysis inhibitor antibody
    see all

画像

  • Anti-Carboxypeptidase B2 antibody (ab78445) at 1 µg/ml + Human liver tissue lysate - total protein (ab29889) at 10 µg

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 48 kDa
    Observed band size : 52 kDa (why is the actual band size different from the predicted?)

プロトコール

参考文献

ab78445 has not yet been referenced specifically in any publications.

レビューと Q&A

There are currently no Customer reviews or Questions for ab78445.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録