Capsazepine, TRPV1 antagonist (ab120025)
Key features and details
- TRPV1 antagonist
- CAS Number: 138977-28-3
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Capsazepine, TRPV1 antagonist -
製品の詳細
TRPV1 antagonist -
生理活性の詳細
TRPV1 vanilloid receptor antagonist (IC50 = 562 nM). Analgesic in vivo.
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CAS 番号
138977-28-3 -
構造式
製品の特性
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体系名
N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide -
分子量
376.90 -
分子式
C19H21ClN2O2S -
PubChem 登録番号
2733484 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Clc1ccc(cc1)CCNC(=S)N2Cc3cc(O)c(O)cc3CCC2 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (7)
ab120025 は 7 報の論文で使用されています。
- Adinolfi B et al. Anticancer activity of anandamide in human cutaneous melanoma cells. Eur J Pharmacol 718:154-9 (2013). PubMed: 24041928
- Yan J et al. Dural afferents express acid-sensing ion channels: a role for decreased meningeal pH in migraine headache. Pain 152:106-13 (2011). PubMed: 20971560
- Ryskamp DA et al. The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells. J Neurosci 31:7089-101 (2011). PubMed: 21562271
- Landucci E et al. CB1 receptors and post-ischemic brain damage: studies on the toxic and neuroprotective effects of cannabinoids in rat organotypic hippocampal slices. Neuropharmacology 60:674-82 (2011). PubMed: 21130785
- De Schepper HU et al. TRPV1 receptor signaling mediates afferent nerve sensitization during colitis-induced motility disorders in rats. Am J Physiol Gastrointest Liver Physiol 294:G245-53 (2008). PubMed: 17991707
- de Man JG et al. Functional study on TRPV1-mediated signalling in the mouse small intestine: involvement of tachykinin receptors. Neurogastroenterol Motil 20:546-56 (2008). PubMed: 18194153
- Cahusac PM & Noyce R A pharmacological study of slowly adapting mechanoreceptors responsive to cold thermal stimulation. Neuroscience 148:489-500 (2007). PubMed: 17683869