製品の概要

  • 製品名Cantharidin
  • 製品の詳細
    Protein phosphatases 1 and 2A (PP1, PP2A) inhibitor
  • 生理活性の詳細Protein phosphatases 1 and 2A (PP1, PP2A) inhibitor (Ki values are 1.1 and 0.19 μM, respectively). Toxin found in Mylabris phalerata. Possesses various biological activities including anticancer, antitumor activity.
  • 精製度> 98%

製品の特性

    アプリケーション

    Our Abpromise guarantee covers the use of ab120967 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    アプリケーション Abreviews 特記事項
    Functional Studies Use at an assay dependent concentration.

    Cantharidin 画像

    • ab7960 staining p21 in PANC-1 cells treated with cantharidin (ab120967), by ICC/IF. Increase of p21 expression correlates with increased concentration of cantharidin, as described in literature.
      The cells were incubated at 37°C for 6h in media containing different concentrations of ab120967 (cantharidin) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab7960 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    Cantharidin (ab120967) 使用論文

    This product has been referenced in:
    • Song Y  et al. Suppression of protein phosphatase 2 differentially modulates VEGF- and FGF2-induced signaling in ovine fetoplacental artery endothelial cells. Placenta 30:907-13 (2009). Read more (PubMed: 19692121) »
    • Rauh R  et al. Molecular biology of cantharidin in cancer cells. Chin Med 2:8 (2007). Read more (PubMed: 17610718) »
    • Narayan P  et al. Phosphatase inhibitor cantharidin blocks adenosine A(1) receptor anti-adrenergic effect in rat cardiac myocytes. Am J Physiol Heart Circ Physiol 278:H1-7 (2000). Read more (PubMed: 10644577) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"