The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse CaM-KIV, catalog ab3557. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (70-fold) for competitive inhibition of antibody-protein binding reactions.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Brain Ca(2+) calmodulin dependent protein kinase type 4
Brain Ca(2+) calmodulin dependent protein kinase type IV
Brain Ca++-calmodulin dependent protein kinase type IV
Calcium / calmodulin dependent protein kinase type 4 catalytic chain
Calcium / calmodulin dependent protein kinase type IV catalytic chain
Calcium/calmodulin dependent protein kinase IV
Calcium/calmodulin dependent protein kinase type IV
Calcium/calmodulin-dependent protein kinase type IV
CAM kinase 4
CAM kinase GR
CAM kinase IV
機能Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role in the consolidation/retention of hippocampus-dependent long-term memory.
組織特異性Expressed in epithelial ovarian cancer tissue.
配列類似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain.
翻訳後修飾Autophosphorylated and phosphorylated by CAMKK1 and CAMKK2 (By similarity). Dephosphorylated by serine/threonine protein phosphatase 2A, probably on Thr-200.
細胞内局在Cytoplasm. Nucleus. Substantial localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear matrix.