The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
追加情報WB: Use at a concentration of 0.5 - 1.0 µg/ml using HEK-293T cells expressing human calsequestrin-2 and extract of rat cardiac muscle (S1 fraction).
Detects a band of approximately 55 kDa (predicted molecular weight: 47 kDa).
Staining of the calsequestrin-2 band is specifically inhibited by the immunizing peptide.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
機能Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. Binds 40 to 50 moles of calcium. Also binds laminin.
配列類似性Belongs to the calsequestrin family.
細胞内局在Sarcoplasmic reticulum lumen. Mitochondrion. This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Also mitochondrial according to PubMed:7945294.
Calsequestrin 1 fast twitch skeletal muscle antibody
Calsequestrin 2 antibody
Calsequestrin 2 fast twitch cardiac muscle antibody
Calsequestrin cardiac muscle isoform antibody
Calsequestrin skeletal muscle isoform antibody
Cardiac calsequestrin 2 antibody
CASQ 1 antibody
CASQ 2 antibody
Skeletal muscle calsequestrin 1 antibody
skeletal muscle isoform antibody
Anti-Calsequestrin antibody (ab62662) 使用論文
This product has been referenced in:
Patel BB et al. Lifelong exposure to bisphenol a alters cardiac structure/function, protein expression, and DNA methylation in adult mice. Toxicol Sci133:174-85 (2013).
Read more (PubMed: 23418087) »
Calvé A et al. Cardiac response to doxorubicin and dexrazoxane in intact and ovariectomized young female rats at rest and after swim training. Am J Physiol Heart Circ Physiol302:H2048-57 (2012).
Read more (PubMed: 22447943) »