Anti-Calreticulin 3 抗体 (ab57346)


  • 製品名Anti-Calreticulin 3 antibody
    Calreticulin 3 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to Calreticulin 3
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 21-385 of Human Calreticulin 3



Our Abpromise guarantee covers the use of ab57346 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR.
    • 組織特異性Testis specific.
    • 関連疾患Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19) [MIM:613875]. CMH19 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    • 配列類似性Belongs to the calreticulin family.
    • ドメインCan be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.
      The interaction with glycans occurs through a binding site in the globular lectin domain.
      The zinc binding sites are localized to the N-domain.
    • 細胞内局在Endoplasmic reticulum lumen.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CALR 3 antibody
      • CALR3 antibody
      • CALR3_HUMAN antibody
      • Calreticulin 2 antibody
      • Calreticulin-2 antibody
      • Calreticulin-3 antibody
      • Calreticulin2 antibody
      • Calreticulin3 antibody
      • Calsperin antibody
      • Cancer/testis antigen 93 antibody
      • CMH19 antibody
      • CRT2 antibody
      • CT93 antibody
      • FLJ25355 antibody
      • MGC26577 antibody
      see all

    Anti-Calreticulin 3 antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab57346 Calreticulin 3 antibody at 1ug/ml. Predicted band size of immunogen is 66 kDa

    Anti-Calreticulin 3 antibody (ab57346) 使用論文

    ab57346 has not yet been referenced specifically in any publications.

    Product Wall

    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application Western blot
    Sample Human Cell lysate - whole cell (HUVEC)
    Loading amount 27 µg
    Specification HUVEC
    Gel Running Conditions Non-reduced Denaturing (7.5% Acrylamide)
    Blocking step Milk as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: RT°C

    Dr. Anna Armoza

    Verified customer

    投稿 Apr 12 2011