Anti-CAPS2 抗体 (ab69794)
Key features and details
- Rabbit polyclonal to CAPS2
- Suitable for: ICC/IF, IHC-P, WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-CAPS2 antibody
CAPS2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to CAPS2 -
由来種
Rabbit -
特異性
specific to CAPS2 and does not recognize CADPS1
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アプリケーション
適用あり: ICC/IF, IHC-P, WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to Human CAPS2 (internal sequence).
Database link: Q86UW7 -
ポジティブ・コントロール
- Human brain cytoplasmic lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab69794の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ICC/IF |
Use a concentration of 20 µg/ml.
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IHC-P |
Use a concentration of 5 µg/ml.
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WB |
Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 147 kDa (predicted molecular weight: 147 kDa).
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特記事項 |
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ICC/IF
Use a concentration of 20 µg/ml. |
IHC-P
Use a concentration of 5 µg/ml. |
WB
Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 147 kDa (predicted molecular weight: 147 kDa). |
ターゲット情報
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関連性
CADPS2 (Ca2+-dependent activator protein for secretion) belongs to the CAPS/Cadps family and consists of two members, CAPS1 and CAPS2. Both members play an important role in secretory granule exocytosis. CADPS2 is involved in the release of two neurotrophins, brain-derived neurotrophic factor and neurotrophin-3, from parallel fibers of cerebellar granule cells. CAPS proteins are expressed predominantly in the brain. CADPS2 has been found in various brain regions including the olfactory bulb, cerebrum, hippocampal formation, thalamus, mesencephalic tegmentum, cerebellum, medulla and spinal cord. CADPS2 colocalizes with proteins related to exocytosis (VAMP and SNAP-25) and endocytosis (Dynamin I) in the cell soma and processes of the mesencephalic tegmentum and cerebellum. -
細胞内局在
Cytoplasmic. Membrane-associated to vesicles. -
参照データベース
- Entrez Gene: 93664 Human
- Omim: 609978 Human
- SwissProt: Q86UW7 Human
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別名
- Cadps2 antibody
- Calcium-dependent activator protein for secretion 2 antibody
- Calcium-dependent secretion activator 2 antibody
see all
画像
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Lane 1 : Anti-CAPS2 antibody (ab69794) at 0.5 µg/ml
Lane 2 : Anti-CAPS2 antibody (ab69794) at 1 µg/ml
All lanes : Human brain tissue lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 147 kDa
Observed band size: 148 kDa why is the actual band size different from the predicted? -
ab69794 at 5 µg/ml staining CAPS2 in human brain tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections).
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Immunofluorescence of CAPS2 in Human Brain cells using ab69794 at 20 ug/ml.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab69794 は 2 報の論文で使用されています。
- Yoo H et al. Down-regulation of habenular calcium-dependent secretion activator 2 induces despair-like behavior. Sci Rep 11:3700 (2021). PubMed: 33580180
- Ayhan F et al. Resolving cellular and molecular diversity along the hippocampal anterior-to-posterior axis in humans. Neuron 109:2091-2105.e6 (2021). PubMed: 34051145