製品の概要

  • 製品名
    CAD peptide

製品の詳細

  • 由来
    Synthetic

特性

Our Abpromise guarantee covers the use of ab8432 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

    Western blot

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

関連情報

  • 別名
    • Aspartate carbamoyltransferase
    • Aspartate transcarbamylase
    • CAD protein
    • CAD trifunctional protein
    • Carbamoyl phosphate synthetase 2
    • Carbamoyl-phosphate synthetase 2 aspartate transcarbamylase and dihydroorotase
    • CPSase ATCase DHOase
    • Dihydroorotase
    • Glutamine dependent carbamoyl phosphate synthase
    • Multifunctional protein CAD
    see all
  • 関連性
    Carbamoyl phosphate synthetase-aspartate carbamoyltransferase-dihydroorotase (CAD) is a multifunctional protein that initiates and regulates mammalian de novo pyrimidine biosynthesis. This trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis is the rate-limiting step in the de novo pyrimidine synthetic pathway. Although most of the CAD protein in the cell is cytosolic, phosphorylation at threonine 456 localizes the protein to the nucleus. While MAPK and EGF phosphorylate CAD at threonine 456, MAPK and c-myc have been found to induce over-expression of CAD.
  • 細胞内局在
    Cytoplasmic and Nuclear

参考文献

ab8432 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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