製品の概要

  • 製品名Anti-CAD antibody
    CAD 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to CAD
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rabbit, Guinea pig, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan, Elephant
  • 免疫原

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to a region within residues 1650 - 1700 of Human CAD (NP_004332.2)

  • ポジティブ・コントロール
    • Breast carcinoma, colon carcinoma, linitis plastica stomach cancer, ovarian carcinoma, stomach adenocarcinoma, testicular seminoma.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab84474 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: 1/100 - 1/500. Antigen retrieval with citrate buffer will enhance staining.
    Note: expected to work on frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 関連性Carbamoyl phosphate synthetase-aspartate carbamoyltransferase-dihydroorotase (CAD) is a multifunctional protein that initiates and regulates mammalian de novo pyrimidine biosynthesis. This trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis is the rate-limiting step in the de novo pyrimidine synthetic pathway. Although most of the CAD protein in the cell is cytosolic, phosphorylation at threonine 456 localizes the protein to the nucleus. While MAPK and EGF phosphorylate CAD at threonine 456, MAPK and c-myc have been found to induce over-expression of CAD.
    • 細胞内局在Cytoplasmic and Nuclear
    • 参照データベース
    • 別名
      • Aspartate carbamoyltransferase antibody
      • Aspartate transcarbamylase antibody
      • CAD protein antibody
      • CAD trifunctional protein antibody
      • Carbamoyl phosphate synthetase 2 antibody
      • CPSase ATCase DHOase antibody
      • Dihydroorotase antibody
      • Glutamine dependent carbamoyl phosphate synthase antibody
      • Multifunctional protein CAD antibody
      see all

    Anti-CAD antibody 画像

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human colon carcinoma, using 1/250 ab84474 followed by DAB staining.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human mucinous ovarian carcinoma, using 1/250 ab84474 followed by DAB staining.

    Anti-CAD antibody (ab84474) 使用論文

    ab84474 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab84474.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"