製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to CACNB4
  • 特異性
    This antibody is expected to recognise all three reported isoforms.
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Cow, Pig, Chinese hamster
  • 免疫原

    Synthetic peptide:

    C-DYPDSYQDTYKPH

    , corresponding to near C terminal amino acids 491-503 of Human CACNB4

  • ポジティブ・コントロール
    • Human Bone Marrow lysate

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab58601 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報
    Peptide ELISA: antibody detection limit dilution 1:4,000.
    WB: Use at a concentration of 0.2 - 0.6 µg/ml. Detects a band of approximately 58 kDa (predicted molecular weight: 58 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
    • 組織特異性
      Expressed predominantly in the cerebellum and kidney.
    • 関連疾患
      Genetic variations in CACNB4 are the cause of susceptibility to idiopathic generalized epilepsy type 9 (IGE9) [MIM:607682]. IGE9 is characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain.
      Genetic variations in CACNB4 are the cause of susceptibility to juvenile myoclonic epilepsy type 6 (EJM6) [MIM:607682]. EJM6 is a subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.
    • 配列類似性
      Belongs to the calcium channel beta subunit family.
      Contains 1 SH3 domain.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CAB4 antibody
      • CACB4_HUMAN antibody
      • Cacnb4 antibody
      • CACNLB4 antibody
      • Calcium channel voltage dependent beta 4 subunit antibody
      • Calcium channel voltage dependent subunit beta 4 antibody
      • Calcium channel voltage-dependent subunit beta 4 antibody
      • Dihydropyridine sensitive L type calcium channel beta 4 subunit antibody
      • EA5 antibody
      • EIG9 antibody
      • EJM antibody
      • EJM4 antibody
      • EJM6 antibody
      • Voltage-dependent L-type calcium channel subunit beta-4 antibody
      see all

    画像

    • Anti-CACNB4 antibody (ab58601) at 0.2 µg/ml + Human Bone Marrow lysate at 35 µg

      Predicted band size : 58 kDa
      Observed band size : 58 kDa

    プロトコール

    参考文献

    ab58601 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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