製品の概要

  • 製品名Anti-CACNB4 antibody
    CACNB4 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to CACNB4
  • 特異性This antibody is expected to recognise all reported protein isoforms of human CACNB4.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat, Pig
  • 免疫原

    Synthetic peptide:

    SPGGYSHDSRHRL

    , corresponding to C terminal amino acids 508-520 of Human CACNB4

  • ポジティブ・コントロール
    • Lysates prepared from human bone marrow. Lysates prepared from transfected HEK293 transiently expressing CACNB4.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline. pH 7.3
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)This antibody has been purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab26060 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 59 kDa).

ターゲット情報

  • 機能The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
  • 組織特異性Expressed predominantly in the cerebellum and kidney.
  • 関連疾患Genetic variations in CACNB4 are the cause of susceptibility to idiopathic generalized epilepsy type 9 (IGE9) [MIM:607682]. IGE9 is characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain.
    Genetic variations in CACNB4 are the cause of susceptibility to juvenile myoclonic epilepsy type 6 (EJM6) [MIM:607682]. EJM6 is a subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.
  • 配列類似性Belongs to the calcium channel beta subunit family.
    Contains 1 SH3 domain.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CAB4 antibody
    • CACB4_HUMAN antibody
    • Cacnb4 antibody
    • CACNLB4 antibody
    • Calcium channel voltage dependent beta 4 subunit antibody
    • Calcium channel voltage dependent subunit beta 4 antibody
    • Calcium channel voltage-dependent subunit beta 4 antibody
    • Dihydropyridine sensitive L type calcium channel beta 4 subunit antibody
    • EA5 antibody
    • EIG9 antibody
    • EJM antibody
    • EJM4 antibody
    • EJM6 antibody
    • Voltage-dependent L-type calcium channel subunit beta-4 antibody
    see all

Anti-CACNB4 antibody 画像

Anti-CACNB4 antibody (ab26060) 使用論文

This product has been referenced in:
  • Mehmood T  et al. Transcriptome profile reveals AMPA receptor dysfunction in the hippocampus of the Rsk2-knockout mice, an animal model of Coffin-Lowry syndrome. Hum Genet 129:255-69 (2011). WB ; Mouse . Read more (PubMed: 21116650) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"