製品の概要

  • 製品名Anti-CACNA2D2 antibody
    CACNA2D2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to CACNA2D2
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Cow, Rhesus monkey
  • 免疫原

    Recombinant fragment corresponding to the internal amino acids 65-163 (PQQHTMQHWA RRLEQEVDGV MRIFGGVQQL REIYKDNRNL FEVQENEPQK LVEKVAGDIE SLLDRKVQAL KRLADAAENF QKAHRWQDNI KEEDIVYY*) of Human CACNA2D2 (NP_006021) linked to a proprietary tag.

  • ポジティブ・コントロール
    • HeLa cell lysate

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab88486 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 130 kDa.
ELISA Use at an assay dependent dilution.

ターゲット情報

  • 機能The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.
  • 組織特異性Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain.
  • 配列類似性Belongs to the calcium channel subunit alpha-2/delta family.
    Contains 1 cache domain.
    Contains 1 VWFA domain.
  • ドメインThe MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.
  • 翻訳後修飾May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role.
  • 細胞内局在Membrane. Colocalizes with CACNA1A in lipid raft fractions.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Alpha 2 delta calcium channel subunit antibody
    • CA2D2_HUMAN antibody
    • CACNA2D antibody
    • Cacna2d2 antibody
    • Calcium channel, voltage-dependent, alpha 2/delta subunit 2 antibody
    • Calcium channel, voltage-dependent, alpha 2/delta subunit 2 gene 26 antibody
    • Gene 26 antibody
    • KIAA0558 antibody
    • LUAC11.1 antibody
    • Voltage-dependent calcium channel subunit alpha-2/delta-2 antibody
    • Voltage-dependent calcium channel subunit delta-2 antibody
    • Voltage-gated calcium channel subunit alpha-2/delta-2 antibody
    see all

Anti-CACNA2D2 antibody 画像

Anti-CACNA2D2 antibody (ab88486) 使用論文

ab88486 has not yet been referenced specifically in any publications.

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Thank you for contacting us. Epitope mapping has not been performed for the monoclonal antibodies ab2864 and ab88486. The other antibodies are polyclonals and will bind at many different sites of the protein. Please let me know if I can be of further a...

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