製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to CABP
  • 特異性
    This antibody is expected to recognise both isoforms.
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide:

    GNCVKYPLRNLS

    , corresponding to N terminal amino acids 2-13 of Human CABP.

  • ポジティブ・コントロール
    • Human Brain lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab2936 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 19 kDa.Can be blocked with Human CABP peptide (ab22942).

ターゲット情報

  • 機能
    Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration.
  • 組織特異性
    Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.
  • 配列類似性
    Contains 4 EF-hand domains.
  • ドメイン
    EF-1 binds magnesium constitutively under physiological conditions, EF-3 and EF-4 bind calcium cooperatively and EF-2 binds neither calcium nor magnesium.
  • 翻訳後修飾
    Phosphorylated. The phosphorylation regulates the activity.
  • 細胞内局在
    Cytoplasm > cell cortex. Cell membrane. S-CaBP1 is localized at or near the plasma membrane; Cytoplasm > cytoskeleton. Cytoplasm > perinuclear region. Cell membrane. Golgi apparatus. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane and Cytoplasm > cytoskeleton. L-CaBP1 is associated most likely with the cytoskeletal structures.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CABP 1 antibody
    • CaBP1 antibody
    • CABP1_HUMAN antibody
    • Calbrain antibody
    • Calcium binding protein 1 antibody
    • Calcium binding protein 5 antibody
    • Calcium-binding protein 1 antibody
    • Caldendrin antibody
    • HCALB BR antibody
    • HCALB_BR antibody
    see all

プロトコール

参考文献

ab2936 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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