製品の概要

  • 製品名
    Anti-C9 antibody [aE11]
    C9 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [aE11] to C9
  • アプリケーション
    適用あり: ELISA, IHC-P, IHC-Fr, Flow Cyt, Functional Studiesmore details
    適用なし: WB
  • 種交差性
    交差種: Horse, Human, Pig
  • 免疫原

    Human purified MAC (membrane attack complex)

  • ポジティブ・コントロール
    • Mucosa from patients with H. Pylori.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS
  • Concentration information loading...
  • 精製度
    Protein A purified
  • 特記事項(精製)
    ab90801 was filtered through a 0.2 µm filter.
  • ポリ/モノ
    モノクローナル
  • クローン名
    aE11
  • アイソタイプ
    IgG2a
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab90801 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent concentration.
IHC-P 1/50.
IHC-Fr 1/50.
Flow Cyt 1/50. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
Functional Studies Use at an assay dependent concentration. aE11 inhibits platelet activation by antiphospholipid antibody serum.
  • 追加情報
    Is unsuitable for WB.
  • ターゲット情報

    • 機能
      Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
    • 組織特異性
      Plasma.
    • 関連疾患
      Defects in C9 are a cause of complement component 9 deficiency (C9D) [MIM:613825]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
    • 配列類似性
      Belongs to the complement C6/C7/C8/C9 family.
      Contains 1 EGF-like domain.
      Contains 1 LDL-receptor class A domain.
      Contains 1 MACPF domain.
      Contains 1 TSP type-1 domain.
    • 翻訳後修飾
      Thrombin cleaves factor C9 to produce C9a and C9b.
      Phosphorylation sites are present in the extracelllular medium.
    • 細胞内局在
      Secreted. Cell membrane. Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore.
    • Information by UniProt
    • 参照データベース
    • 別名
      • ARMD15 antibody
      • C9 antibody
      • C9 deficiency antibody
      • C9 deficiency with dermatomyositis antibody
      • C9D antibody
      • CO9_HUMAN antibody
      • Complement component 9 antibody
      • Complement component 9 deficiency antibody
      • Complement component C9 antibody
      • Complement component C9b antibody
      see all

    画像

    • Detection of TCC with ab90801 diluted 20x in PBSA.

    参考文献

    This product has been referenced in:
    • Meuwissen M  et al. Colocalisation of intraplaque C reactive protein, complement, oxidised low density lipoprotein, and macrophages in stable and unstable angina and acute myocardial infarction. J Clin Pathol 59:196-201 (2006). IHC-Fr ; Human . Read more (PubMed: 16443738) »
    • Berstad AE  et al. Epithelium related deposition of activated complement in Helicobacter pylori associated gastritis. Gut 40:196-203 (1997). IHC-P, IF ; Human . Read more (PubMed: 9071931) »

    See all 5 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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