製品の概要

  • 製品名
    Anti-C4c+C4b antibody (FITC)
  • 製品の詳細
    Rabbit polyclonal to C4c+C4b (FITC)
  • 標識
    FITC. Ex: 493nm, Em: 528nm
  • 特異性
    This antibody reacts with human C4, C4b and C4c but does not react with the C4d epitope.
  • アプリケーション
    適用あり: IHC-Fr, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    C4c complement isolated from complement activated human serum.

  • 特記事項

    Fluorescein isothiocyanate (FITC) isomer 1.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C.
  • バッファー
    Preservative: 0.05% Sodium Azide
    Constituents: 1% BSA, PBS
  • Concentration information loading...
  • 精製度
    IgG fraction
  • 特記事項(精製)
    Traces of contaminating antibodies have been removed by solid phase absorption with human plasma proteins.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab4216 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr 1/50 - 1/100.

Incubate for 30 - 60 min at room temperature. Optimal dilutions / concentrations should be determined by the end user.

IHC-P 1/50 - 1/100.

Incubate for 30 - 60 min at room temperature. Optimal dilutions / concentrations should be determined by the end user.

ターゲット情報

  • 関連性
    C4 plays a central role in the activation of the classical pathway of the complement system. Human complement component C4 is polymorphic at two loci, C4A and C4B. The C4A alleles carry the Rodgers (Rg) while the C4B alleles carry the Chido (Ch) blood group antigens. C4 (either allele A or B) protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.
  • 細胞内局在
    Secreted
  • 参照データベース
  • 別名
    • Acidic complement C4 antibody
    • Basic complement C4 antibody
    • CH antibody
    • Chido blood group antibody
    • Complement component 4A antibody
    • Complement component 4B antibody
    • RG antibody
    • Rodgers blood group antibody
    see all

プロトコール

参考文献

ab4216 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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