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Recombinant fragment, corresponding to amino acids 161-332 of Human C3a Receptor, corresponding to its second extracellular loop.
C3a is an anaphylatoxin generated through activation of the complement C3, and is a potent chemoattractant for phagocytes, and stimulates chemotaxis and other leukocyte functions. C3a binds to eosinophils, basophils, neutrophils, and differentiated U937 cells, that all express receptors for C3a on their cell surface. The C3a receptor has been cloned and shown to be a G protein-coupled receptor with seven putative transmembrane domains (Crass 1996, Ames 1996). This receptor is characterized for its large extracellular loop between the fourth and fifth transmembrane domains (Roglic 1996). The loop can be readily detected using the rabbit anti-C3a receptor antibody.
Our Abpromise guarantee covers the use of ab7209 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Flow Cyt||Use at an assay dependent concentration.|
ab7209 has not yet been referenced specifically in any publications.
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