製品の概要
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製品名Anti-C2 antibody [5C3]
C2 一次抗体 製品一覧 -
製品の詳細Mouse monoclonal [5C3] to C2
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特異性This antibody reacts with C2 and a subfraction of C2 believed to be C2b
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アプリケーション適用あり: ELISA, WBmore details
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種交差性交差種: Human
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免疫原
Full length native complement component C2 protein isolated from human plasma.
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エピトープEpitope specificity differs from that of ab17452 as determined by inhibition ELISA.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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バッファーPreservative: None
Constituents: 0.5M Sodium chloride, 0.01M PBS, pH 7.4 -
Concentration information loading... -
精製度Protein A purified
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ポリ/モノモノクローナル
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クローン名5C3
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ミエローマx63-Ag8.653
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アイソタイプIgG2a
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軽鎖の種類kappa
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab17451 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ELISA | 1/12000. | |
| WB | Use at an assay dependent dilution. Predicted molecular weight: 102 kDa. |
ターゲット情報
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機能Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor 4b to generate the C3 or C5 convertase.
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関連疾患Defects in C2 are the cause of complement component 2 deficiency (C2D) [MIM:217000]. A deficiency of the complement classical pathway associated with the development of autoimmune disorders, mainly systemic lupus erythematosus. Skin and joint manifestations are common and renal disease is relatively rare. Patients with complement component 2 deficiency are also reported to have recurrent or invasive infections.
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配列類似性Belongs to the peptidase S1 family.
Contains 1 peptidase S1 domain.
Contains 3 Sushi (CCP/SCR) domains.
Contains 1 VWFA domain. -
細胞内局在Secreted.
- Information by UniProt
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参照データベース
- Entrez Gene: 717 Human
- Omim: 217000 Human
- SwissProt: P06681 Human
- Unigene: 408903 Human
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別名
- ARMD14 antibody
- C2 antibody
- C3/C5 convertase antibody
see all
プロトコール
Anti-C2 antibody [5C3] (ab17451) 使用論文
This product has been referenced in:
- Rorbach J et al. PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria. Nucleic Acids Res : (2011). WB ; Human . Read more (PubMed: 21666256) »
- Stenbaek EI et al. Human complement component C2: production and characterization of polyclonal and monoclonal antibodies against C2. Mol Immunol 23:879-86 (1986). Read more (PubMed: 3796629) »
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"