Anti-C1QC 抗体 [EPR2984Y] (ab75756)

製品の概要

  • 製品名Anti-C1QC antibody [EPR2984Y]
    C1QC 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR2984Y] to C1QC
  • アプリケーション適用あり: WB, IP, IHC-P, ICC, Flow Cytmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to residues in human C1q (subunit C)

  • ポジティブ・コントロール
    • Human plasma lysate and human liver tissue.
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab75756 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 26 kDa (predicted molecular weight: 26 kDa).
IP 1/10.
IHC-P 1/100 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
ICC 1/250 - 1/500.
Flow Cyt 1/50.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
  • 関連疾患Defects in C1QC are a cause of complement component C1q deficiency (C1QD) [MIM:613652]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
  • 配列類似性Contains 1 C1q domain.
    Contains 1 collagen-like domain.
  • 翻訳後修飾O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AI385742 antibody
    • C1Q C antibody
    • C1qc antibody
    • C1QC_HUMAN antibody
    • C1QG antibody
    • Complement C1q subcomponent subunit C antibody
    • Complement component 1, q subcomponent, C chain antibody
    • complement component 1, q subcomponent, gamma polypeptide antibody
    see all

Anti-C1QC antibody [EPR2984Y] 画像

  • ab75756 at 1/100 dilution staining C1q in human liver by Immunohistochemistry, Paraffin-embedded tissue.
  • Anti-C1QC antibody [EPR2984Y] (ab75756) at 1/1000 dilution + human plasma lysate at 10 µg

    Secondary
    goat anti-rabbit HRP at 1/2000 dilution

    Predicted band size : 26 kDa
    Observed band size : 26 kDa

Anti-C1QC antibody [EPR2984Y] (ab75756) 使用論文

ab75756 has not yet been referenced specifically in any publications.

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The Anti-C1QC antibody [EPR2984Y] (ab75756) is a tissue culture supernatant antibody. I can confirm that tissue culture tissue supernatant contains not only the pure antibody, but also other proteins and we do not regularly determine those concentratio...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"