Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling.
Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle.
Detection of C1orf80 by Western Blot of Immunprecipitate.
ab117780 at 0.4µg/ml staining C1orf80 in HeLa whole cell lysate immunoprecipitated using ab117780 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 10 seconds.