製品の概要

  • 製品名Anti-C1orf77 antibody
    C1orf77 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to C1orf77
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 71-120 (LKQSLKQRLG KSNIQARLGR PIGALARGAI GGRGLPIIQR GLPRGGLRGG) of Human C1orf77 (NP_056422).

  • ポジティブ・コントロール
    • THP1 cell lysate

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab101973 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 26 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789).
    Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity (PubMed:23299939).
  • 組織特異性Expressed in an erythroid progenitor cell line derived from peripheral blood. Expressed in glioblastoma cells (PubMed:25284789).
  • 翻訳後修飾Asymmetrically methylated by PRMT1 (PubMed:25284789). Symmetrically methylated by PRMT5.
  • 細胞内局在Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Mostly associated with facultative heterochromatin (By similarity). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (PubMed:23826332).
  • Information by UniProt
  • 参照データベース
  • 別名
    • C1orf77 antibody
    • chromatin target of chromatin target of PRMT1 protein antibody
    • Chromatin target of PRMT1 antibody
    • Chromatin target of PRMT1 protein antibody
    • Chromosome 1 open reading frame 77 antibody
    • CHTOP antibody
    • CHTOP_HUMAN antibody
    • DKFZp547E1010 antibody
    • FL- RP1-178F15.2 antibody
    • FL-SRAG antibody
    • FOP antibody
    • Friend of PRMT1 antibody
    • Friend of PRMT1 protein antibody
    • HT031 antibody
    • MGC131924 antibody
    • MGC86949 antibody
    • OTTHUMP00000035122 antibody
    • OTTHUMP00000035123 antibody
    • Pp7704 antibody
    • RP1 178F15.2 antibody
    • Small arginine- and glycine-rich protein antibody
    • Small protein rich in arginine and glycine antibody
    • SRAG antibody
    • SRAG-3 antibody
    • SRAG-5 antibody
    see all

Anti-C1orf77 antibody 画像

  • Anti-C1orf77 antibody (ab101973) at 1 µg/ml + THP1 cell lysate at 10 µg

    Predicted band size : 26 kDa

Anti-C1orf77 antibody (ab101973) 使用論文

ab101973 has not yet been referenced specifically in any publications.

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