Anti-C1GALT1C1 抗体 (ab68310)

製品の概要

• 製品名
  Anti-C1GALT1C1 antibody
  C1GALT1C1 一次抗体 製品一覧
• 製品の詳細
  Mouse polyclonal to C1GALT1C1
• 特異性
  This antibody is reactive against mammalian transfected lysate.
• アプリケーション
  適用あり: WB, ICC/IFmore details
• 種交差性
  交差種: Human
  
• 免疫原

  C1GALT1C1 (NP_001011551.1, 1 a.a. ~ 318 a.a) full-length human protein.

• ポジティブ･コントロール
  • C1GALT1C1 transfected 293T cell lysate an human liver tissue lysate

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• バッファー
  Preservative: None
  Constituents: 1X PBS, pH 7.2
• Concentration information loading...
• 精製度
  Protein G purified
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Signal Transduction
  • Metabolism
  • Amino Acids

  • Signal Transduction
  • Protein Trafficking
  • Chaperones
  • Other Chaperones

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Amino acid metabolism

  • Metabolism
  • Types of disease
  • Cancer

関連製品

• Compatible Secondaries
  • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
  • Goat Anti-Mouse IgG H&L (HRP) (ab205719)

アプリケーション

ターゲット情報

• 機能
  Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1).
• 組織特異性
  Ubiquitously expressed. Abundantly expressed in salivary gland, stomach, small intestine, kidney, and testis and at intermediate levels in whole brain, cerebellum, spinal cord, thymus, spleen, trachea, lung, pancreas, ovary, and uterus.
• 関連疾患
  Defects in C1GALT1C1 are the cause of Tn syndrome (TNSYN) [MIM:300622]. Tn syndrome is a rare autoimmune disease caused by somatic mutation in the C1GALT1C1 gene in which subpopulations of blood cells of all lineages carry an incompletely glycosylated membrane glycoprotein, i.e. the Tn antigen. Since leukocytes and platelets are affected as well as red cells, anemia, leukopenia and thrombocytopenia are features. Tn-polyagglutinability is sometimes associated with leukemia or is a preleukemic state.
• 配列類似性
  Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
• 細胞内局在
  Membrane.

• Target information above from: UniProt accession Q96EU7 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 29071 Human
  • Omim: 300611 Human
  • SwissProt: Q96EU7 Human
  • Unigene: 643920 Human
• 別名
  • HSPC067 antibody
  • 3-galactosyltransferase 2 antibody
  • Beta 1,3 galactosyltransferase 2 antibody

  • Beta1,3 galactosyltransferase 2 antibody
  • C1Gal T2 antibody
  • C1Gal-T2 antibody
  • C1GALT1 specific chaperone 1 antibody
  • C1GALT1-specific chaperone 1 antibody
  • C1galt1c1 antibody
  • C1GalT2 antibody
  • C1GLC_HUMAN antibody
  • C38H2 L1 antibody
  • C38H2 like protein 1 antibody
  • C38H2-L1 antibody
  • C38H2-like protein 1 antibody
  • C38H2L1 antibody
  • Core 1 beta1 antibody
  • Core 1 beta3 galactosyltransferase specific molecular chaperone antibody
  • Core 1 beta3-Gal-T2 antibody
  • Core 1 beta3-galactosyltransferase-specific molecular chaperone antibody
  • Core 1 UDP galactose:N acetylgalactosamine alpha R beta 1,3 galactosyltransferase 2 antibody
  • COSMC antibody
  • MGC19947 antibody
  • MST143 antibody

  see all

プロトコール

• Western blot protocols
• Immunocytochemistry & immunofluorescence protocols