製品の概要

  • 製品名Anti-C1 Inactivator antibody
    C1 Inactivator 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to C1 Inactivator
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 77-390 of Human C1 Inactivator (NP_000053).

  • ポジティブ・コントロール
    • 293T, A431, H1299, HeLa S3, HepG2, MOLT4 and Raji cell lysates.

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab97348 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 55 kDa.

ターゲット情報

  • 機能Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
  • 関連疾患Defects in SERPING1 are the cause of hereditary angioedema (HAE) [MIM:106100]; also called hereditary angioneurotic edema (HANE). HAE is an autosomal dominant disorder characterized by episodic local subcutaneous edema and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In HAE type 1, representing 85% of patients, serum levels of C1 esterase inhibitor are less than 35% of normal. In HAE type 2, the levels are normal or elevated, but the protein is non-functional.
  • 配列類似性Belongs to the serpin family.
  • 翻訳後修飾Highly glycosylated (49%) with N- and O-glycosylation.
    Can be proteolytically cleaved by E.coli stcE.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • C1 esterase inhibitor antibody
    • C1 Inh antibody
    • C1 inhibiting factor antibody
    • C1 inhibitor antibody
    • C1-inhibiting factor antibody
    • C1IN antibody
    • C1Inh antibody
    • C1NH antibody
    • complement component 1 inhibitor antibody
    • esterase inhibitor antibody
    • HAE1 antibody
    • HAE2 antibody
    • IC1_HUMAN antibody
    • Plasma protease C1 inhibitor antibody
    • Serine (or cysteine) proteinase inhibitor clade G member 1 antibody
    • serine/cysteine proteinase inhibitor clade G member 1 antibody
    • Serpin G1 antibody
    • serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 antibody
    • SERPING1 antibody
    see all

Anti-C1 Inactivator antibody 画像

  • All lanes : Anti-C1 Inactivator antibody (ab97348) at 1/1000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : HeLa S3 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 55 kDa

Anti-C1 Inactivator antibody (ab97348) 使用論文

This product has been referenced in:
  • Hansen HG  et al. Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells. Sci Rep 5:18016 (2015). WB . Read more (PubMed: 26657798) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab97348.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"