Anti-c-Myc 抗体 [SPM237], prediluted (ab17767)


  • 製品名
    Anti-c-Myc antibody [SPM237], prediluted
    c-Myc 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [SPM237] to c-Myc, prediluted
  • 特異性
    The protein detected by ab17767 is 64-67kDa
  • アプリケーション
    適用あり: IHC-P, IHC-FoFrmore details
  • 種交差性
    交差種: Human
    非交差種: Mouse, Rat, Chicken
  • 免疫原

    Synthetic peptide, corresponding to C terminal amino acids 408-439 of Human c-Myc.

  • エピトープ
  • ポジティブ・コントロール
    • Raji cells, Breast carcinoma



Our Abpromise guarantee covers the use of ab17767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
  • 追加情報
    Immunohistology (Formalin/paraffin). Working dilution: ab17767 is ready-to-use for 30 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. The optimal dilution for a specific application should be determined by the investigator.
  • ターゲット情報

    • 機能
      Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
    • 関連疾患
      Note=Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors.
      Note=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.
      Defects in MYC are a cause of Burkitt lymphoma (BL) [MIM:113970]. A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. Note=Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci.
    • 配列類似性
      Contains 1 basic helix-loop-helix (bHLH) domain.
    • 翻訳後修飾
      Phosphorylated by PRKDC. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome.
      Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex.
    • 細胞内局在
      Nucleus > nucleoplasm. Nucleus > nucleolus.
    • Information by UniProt
    • 参照データベース
    • 製品の状態
      c-Myc is also expressed in the cytoplasm.
    • 別名
      • AU016757 antibody
      • Avian myelocytomatosis viral oncogene homolog antibody
      • bHLHe39 antibody
      • c Myc antibody
      • Class E basic helix-loop-helix protein 39 antibody
      • MRTL antibody
      • Myc antibody
      • Myc protein antibody
      • Myc proto oncogene protein antibody
      • Myc proto-oncogene protein antibody
      • myc-related translation/localization regulatory factor antibody
      • MYC_HUMAN antibody
      • Myc2 antibody
      • MYCC antibody
      • Myelocytomatosis oncogene antibody
      • Niard antibody
      • Nird antibody
      • Oncogene Myc antibody
      • OTTHUMP00000158589 antibody
      • Proto-oncogene c-Myc antibody
      • Protooncogene homologous to myelocytomatosis virus antibody
      • RNCMYC antibody
      • Transcription factor p64 antibody
      • Transcriptional regulator Myc-A antibody
      • V-Myc avian myelocytomatosis viral oncogene homolog antibody
      • v-myc myelocytomatosis viral oncogene homolog (avian) antibody
      see all

    Anti-c-Myc antibody [SPM237], prediluted 画像

    • Formalin fixed human breast carcinoma stained with anti-c-myc (ab17767)


    Anti-c-Myc antibody [SPM237], prediluted (ab17767) 使用論文

    ab17767 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab17767.
    Please use the links above to contact us or submit feedback about this product.