製品の概要

  • 製品名Anti-c Abl antibody
    c Abl 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to c Abl
  • 特異性Detects endogenous levels of total c Abl protein.
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic non-phosphopeptide derived from human c Abl around the phosphorylation site of tyrosine 204 (K-L-YP-V-S).

  • ポジティブ・コントロール
    • COS7 cells.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab63530 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/10000.
WB 1/500 - 1/1000. Detects a band of approximately 123 kDa (predicted molecular weight: 123 kDa).

ターゲット情報

  • 機能Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
  • 組織特異性Widely expressed.
  • 関連疾患Note=A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
  • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • 翻訳後修飾Phosphorylated by PRKDC (By similarity). DNA damage-induced activation of c-Abl requires the function of ATM and Ser-446 phosphorylation (By similarity). Phosphorylation on Thr-735 is required for binding 14-3-3 proteins for cytoplasmic translocation.
    Isoform IB is myristoylated on Gly-2.
  • 細胞内局在Cytoplasm > cytoskeleton. Nucleus. Sequestered into the cytoplasm through interaction with 14-3-3 proteins and Nucleus membrane. The myristoylated c-ABL protein is reported to be nuclear.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Abelson murine leukemia viral oncogene homolog 1 antibody
    • Abelson tyrosine protein kinase 1 antibody
    • Abl 1 antibody
    • ABL antibody
    • ABL proto oncogene 1 non receptor tyrosine kinase antibody
    • ABL1 antibody
    • ABL1_HUMAN antibody
    • bcr/abl antibody
    • bcr/c abl oncogene protein antibody
    • c ABL antibody
    • c abl oncogene 1 non receptor tyrosine kinase antibody
    • c abl oncogene 1 receptor tyrosine kinase antibody
    • c ABL1 antibody
    • JTK7 antibody
    • p150 antibody
    • Proto oncogene tyrosine protein kinase ABL1 antibody
    • Proto-oncogene c-Abl antibody
    • Tyrosine-protein kinase ABL1 antibody
    • v abl Abelson murine leukemia viral oncogene homolog 1 antibody
    • v abl antibody
    see all

Anti-c Abl antibody 画像

  • All lanes : Anti-c Abl antibody (ab63530) at 1/500 dilution

    Lane 1 : Extracts from COS7 cells (5µg), treated with Adriamycin (0.5µg/ml, 24hours)
    Lane 2 : Extracts from COS7 cells (5µg), treated with Adriamycin (0.5µg/ml, 24hours), with immunizing non-phpophopeptide at 5 µg


    Predicted band size : 123 kDa
    Observed band size : 123 kDa

Anti-c Abl antibody (ab63530) 使用論文

ab63530 has not yet been referenced specifically in any publications.

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