製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to BRSK1
  • アプリケーション
    適用あり: WB, IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to Human BRSK1 (C terminal).

  • ポジティブ・コントロール
    • Human brain cortex tissue

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファー
    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab115475 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 87 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 20 µg/ml.

ターゲット情報

  • 機能
    Required for the polarization of forebrain neurons which endows axons and dendrites with distinct properties, possibly by locally regulating phosphorylation of microtubule-associated proteins (By similarity). May be involved in the regulation of G2/M arrest in response to UV- or methyl methane sulfonate (MMS)-induced, but not IR-induced, DNA damage. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo.
  • 組織特異性
    Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.
  • 配列類似性
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.
    Contains 1 protein kinase domain.
    Contains 1 UBA domain.
  • 細胞内局在
    Cytoplasm. Nucleus. Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage.
  • Information by UniProt
  • 参照データベース
  • 別名
    • BR serine/threonine kinase 1 antibody
    • BR serine/threonine protein kinase 1 antibody
    • BR serine/threonine-protein kinase 1 antibody
    • Brain selective kinase 1 antibody
    • Brain-specific serine/threonine-protein kinase 1 antibody
    • BRSK 1 antibody
    • Brsk1 antibody
    • BRSK1_HUMAN antibody
    • FLJ43009 antibody
    • hSAD1 antibody
    • KIAA1811 antibody
    • Protein kinase SAD1A antibody
    • SAD 1 antibody
    • SAD1 antibody
    • SAD1 homolog antibody
    • SAD1 kinase antibody
    • SAD1A antibody
    • SADB antibody
    • SadB kinase short isoform antibody
    • Serine/threonine kinase SAD B antibody
    • Serine/threonine-protein kinase SAD-B antibody
    • Synapses of Amphids Defective homolog antibody
    see all

画像

  • ab115475, at 5µg/ml, staining BRSK1 in formalin-fixed, paraffin-embedded Human brain cortex tissue by immunohistochemistry using a biotinylated anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Lane 1 : Anti-BRSK1 antibody (ab115475) at 0.5 µg/ml
    Lane 2 : Anti-BRSK1 antibody (ab115475) at 1 µg/ml

    Lane 1 : Human brain tissue lysate
    Lane 2 : Human brain tissue lysate


    Predicted band size : 87 kDa

参考文献

ab115475 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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