製品の概要

  • 製品名Anti-BRRN1 antibody - Carboxyterminal end
    BRRN1 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to BRRN1 - Carboxyterminal end
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide:

    C-TEDLSDVLVRQGD

    , corresponding to C terminal amino acids 729-741 of Human BRRN1

  • ポジティブ・コントロール
    • K562 cell lysate.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab62815 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.01 - 0.03 µg/ml. Detects a band of approximately 110 kDa (predicted molecular weight: 82 kDa).
ELISA 1/128000.

ターゲット情報

  • 機能Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
  • 組織特異性Widely expressed at low level. Expressed in proliferating cells.
  • 配列類似性Belongs to the CND2 (condensin subunit 2) family.
  • 翻訳後修飾Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation.
  • 細胞内局在Nucleus. Cytoplasm. Chromosome. In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Barren Drosophila Homolog of 1 antibody
    • Barren homolog protein 1 antibody
    • BRRN antibody
    • BRRN1 antibody
    • CAP H antibody
    • CAPH antibody
    • Chromosome associated protein H antibody
    • Chromosome-associated protein H antibody
    • CND2_HUMAN antibody
    • Condensin complex subunit 2 antibody
    • Condensin subunit 2 antibody
    • Condensin-2 complex subunit H2 antibody
    • Condesin antibody
    • HCAP H antibody
    • hCAP-H antibody
    • KIAA0074 antibody
    • mCAP H antibody
    • MGC4616 antibody
    • Ncaph antibody
    • Non SMC condensin I complex subunit H antibody
    • Non-SMC condensin I complex subunit H antibody
    • XCAP H homolog antibody
    • XCAP-H homolog antibody
    see all

Anti-BRRN1 antibody - Carboxyterminal end 画像

Anti-BRRN1 antibody - Carboxyterminal end (ab62815) 使用論文

This product has been referenced in:
  • Pan X  et al. YY1 controls Ig? repertoire and B-cell development, and localizes with condensin on the Ig? locus. EMBO J 32:1168-82 (2013). Read more (PubMed: 23531880) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"