製品の概要

  • 製品名
    Bromocriptine mesylate
  • 製品の詳細
    Potent, selective D2-like dopamine receptor agonist
  • 生理活性の詳細
    Potent, selective D2-like dopamine receptor agonist (Ki values are ~8 (D2), ~5 (D3), ~290 (D4), ~440 (D1) and ~450 nM (D5)). Inhibits the release of pituitary prolactin and stimulates motor activity in Parkinson's disease. Also reverses glutamate transporter 1 (GLT-1) activity, increasing glutamate levels.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Shirasaki Y  et al. Bromocriptine, an ergot alkaloid, inhibits excitatory amino acid release mediated by glutamate transporter reversal. Eur J Pharmacol 643:48-57 (2010). Read more (PubMed: 20599932) »
  • Lindgren HS  et al. Differential involvement of D1 and D2 dopamine receptors in L-DOPA-induced angiogenic activity in a rat model of Parkinson's disease. Neuropsychopharmacology 34:2477-88 (2009). Read more (PubMed: 19606087) »
  • Valente D  et al. Metabolite involvement in bromocriptine-induced prolactin inhibition in rats. J Pharmacol Exp Ther 282:1418-24 (1997). Read more (PubMed: 9316855) »
  • Seeman P & Van Tol HH Dopamine receptor pharmacology. Trends Pharmacol Sci 15:264-70 (1994). Read more (PubMed: 7940991) »

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