製品の概要

  • 製品名
    Brilliant Blue G
  • 製品の詳細
    Potent, noncompetitive P2X7 antagonist
  • 別名
    • Acid blue 90
    • Coomassie® Brilliant Blue G
  • 生理活性の詳細
    Potent, non-competitive antagonist of rat and human P2X7 receptors (IC50 values are 10 and 200 nM, respectively). Displays >1000-fold selectivity over P2X4. IC50 values for inhibition of the other P2X receptors range from 2 to >30 µM. Rat and human P2X4 receptors show IC50 values of >10 and 3.2 µM, respectively.

製品の特性

  • 体系名
    N-[4-[[4-[(4-Ethoxyphenyl)amino]phenyl][4-[ethyl[(3-sulfophenyl)methyl]amino]-2-methylphenyl]methylene]-3-methyl-2,5-cyclohexadien-1-ylidene]-N-ethyl-3-sulfobenzenemethanaminium , inner salt, sodium salt
  • 分子量
    854.02
  • 構造式
    Chemical Structure
  • 分子式
    C47H48N3NaO7S2
  • CAS 番号
    6104-58-1
  • PubChem 登録番号
    61363
  • 保存方法
    Store at Room Temperature. The product can be stored for up to 12 months.
  • 溶解性
    Soluble in water to 50 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記
    CC/[N+](Cc1cccc(c1)S([O-])(=O)=O)=C2/C=C/C(C(C)=C2)=C(/c4ccc(Nc3ccc(OCC)cc3)cc4)c5ccc(cc5C)N(Cc6cccc(c6)S(=O)(=O)O[Na])CC
  • 由来

    Synthetic

  • 研究分野

参考文献

This product has been referenced in:
  • Ryu JK & McLarnon JG Block of purinergic P2X(7) receptor is neuroprotective in an animal model of Alzheimer's disease. Neuroreport 19:1715-9 (2008). Read more (PubMed: 18852683) »
  • Michel AD  et al. Direct labelling of the human P2X7 receptor and identification of positive and negative cooperativity of binding. Br J Pharmacol 151:103-14 (2007). Read more (PubMed: 17339830) »
  • Jiang LH  et al. Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors. Mol Pharmacol 58:82-8 (2000). Read more (PubMed: 10860929) »

See 0 Publications for this product

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