Potent, non-competitive antagonist of rat and human P2X7 receptors (IC50 values are 10 and 200 nM, respectively). Displays >1000-fold selectivity over P2X4. IC50 values for inhibition of the other P2X receptors range from 2 to >30 µM. Rat and human P2X4 receptors show IC50 values of >10 and 3.2 µM, respectively.
N-[4-[[4-[(4-Ethoxyphenyl)amino]phenyl][4-[ethyl[(3-sulfophenyl)methyl]amino]-2-methylphenyl]methylene]-3-methyl-2,5-cyclohexadien-1-ylidene]-N-ethyl-3-sulfobenzenemethanaminium , inner salt, sodium salt
Store at Room Temperature. The product can be stored for up to 12 months.
Soluble in water to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.