製品の概要

  • 製品名Anti-Bradykinin antibody
    Bradykinin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Bradykinin
  • 特異性Bradykinin: 100%. Although the immunogen for this antibody was the 9-amino acid peptide, bradykinin, conjugated to BSA the antibody recognizes both free and endogenous bradykinin in ELISA.
  • アプリケーション適用あり: ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length protein (Human) conjugated to BSA.

  • 特記事項For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Supplied as a liquid serum, 40% glycerol

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab14391 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/250 - 1/500.

ターゲット情報

  • 機能(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
  • 組織特異性Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors.
  • 関連疾患Defects in KNG1 are the cause of high molecular weight kininogen deficiency (HMWK deficiency) [MIM:228960]. HMWK deficiency is an autosomal recessive coagulation defect. Patients with HWMK deficiency do not have a hemorrhagic tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis.
  • 配列類似性Contains 3 cystatin domains.
  • 翻訳後修飾Bradykinin is released from kininogen by plasma kallikrein.
    Hydroxylation of Pro-383 occurs prior to the release of bradykinin.
    Phosphorylation sites are present in the extracelllular medium.
    N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
  • 細胞内局在Secreted > extracellular space.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Alpha-2-thiol proteinase inhibitor antibody
    • BDK antibody
    • Fitzgerald factor antibody
    • High molecular weight kininogen antibody
    • HMWK antibody
    • Ile-Ser-Bradykinin antibody
    • Kallidin I antibody
    • Kallidin II antibody
    • Kininogen 1 antibody
    • KNG antibody
    • KNG1 antibody
    • KNG1_HUMAN antibody
    • Low molecular weight growth-promoting factor antibody
    • Williams-Fitzgerald-Flaujeac factor antibody
    see all

Anti-Bradykinin antibody (ab14391) 使用論文

ab14391 has not yet been referenced specifically in any publications.

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Thank you for your inquiry.

I can confirm that ab14391 recognizes Lys-Bradykinin (Kallidin).

It does not recognize [Des-Arg9]-Bradykinin.

The characterization of this antibody was performed by RIA.

I hope this in...

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Thank you for your inquiry.

For the three of our bradykinin antibodies, ab47864, ab14391and ab47686, the immunogen used was from a.a. 381- 389 of the human sequence (RPPGFSPFR).

You can see any testing information on the online data...

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Thank you for contacting us. This antibody has not been tested for neutralizing capability in cell culture and so we can not speak to its potential in that use. I hope this information is helpful to you. Please do not hesitate to contact us if you...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"