製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to BPTF / FALZ
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Chimpanzee, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 1350-1400 of Human BPTF/ FALZ (NP_872579.2).

  • ポジティブ・コントロール
    • Human Breast Carcinoma, Colon Carcinoma, Ovarian Carcinoma, Prostate Carcinoma and Testicular Seminoma tissues.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab99399 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with tris-EDTA pH9.0 buffer will enhance staining.

ターゲット情報

  • 機能
    Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
  • 組織特異性
    Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).
  • 配列類似性
    Belongs to the PBTF family.
    Contains 1 bromo domain.
    Contains 1 DDT domain.
    Contains 2 PHD-type zinc fingers.
  • 発生段階
    Abundantly expressed in the fetal brain. Present throughout the gray and white matter of the developing spinal cord at 18-22 gestational weeks. Expressed at low levels in adult brain and spinal cord and reexpressed in neurodegenerative diseases (at protein level).
  • ドメイン
    The second PHD-type zinc finger mediates binding to histone H3K4Me3. Has specificity for trimethyllysine; introducing a mutation in the Tyr-2876 residue can induce binding to dimethyllysine.
  • 翻訳後修飾
    Phosphorylation enhances DNA-binding.
    Highly susceptible to proteolysis.
  • 細胞内局在
    Cytoplasm. Nucleus. In brains of Alzheimer disease patients, present in a subset of amyloid-containing plaques.
  • Information by UniProt
  • 参照データベース
  • 別名
    • BPTF antibody
    • BPTF_HUMAN antibody
    • Bromodomain and PHD finger containing transcription factor antibody
    • Bromodomain and PHD finger-containing transcription factor antibody
    • Bromodomain PHD finger transcription factor antibody
    • FAC 1 antibody
    • fac1 antibody
    • FALZ antibody
    • Fetal Alz 50 clone 1 protein antibody
    • Fetal Alz 50 reactive clone 1 antibody
    • Fetal Alz-50 clone 1 protein antibody
    • Fetal Alzheimer antigen antibody
    • Nucleosome remodeling factor antibody
    • Nucleosome remodeling factor subunit BPTF antibody
    • Nucleosome remodeling factor, large subunit antibody
    • Nucleosome-remodeling factor subunit BPTF antibody
    • NURF 301 antibody
    • NURF301 antibody
    see all

Anti-BPTF / FALZ antibody 画像

  • ab99399, at 1/250 dilution, staining BPTF / FALZ in formalin-fixed, paraffin-embedded Human breast carcinoma by Immunohistochemistry. Detection: DAB staining.
  • ab99399, at 1/250 dilution, staining BPTF / FALZ in formalin-fixed, paraffin-embedded Human colon carcinoma by Immunohistochemistry. Detection: DAB staining.

プロトコール

Anti-BPTF / FALZ antibody (ab99399) 使用論文

ab99399 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab99399.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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