The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.1 - 1 µg/ml. Detects a band of approximately 18 kDa (predicted molecular weight: 14 kDa).
Use a concentration of 0.01 - 0.1 µg/ml.
Use a concentration of 2 - 5 µg/ml.
機能Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
組織特異性Brain and also in atria, but at much lower levels than ANP.
配列類似性Belongs to the natriuretic peptide family.
翻訳後修飾The brain natriuretic peptide 32 form is cleaved at Pro-104 by the prolyl endopeptidase FAP (seprase) activity (in vitro).