製品の概要

製品の詳細

  • 由来
    Synthetic

関連製品

特性

Our Abpromise guarantee covers the use of ab8431 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    Blocking

  • 製品の状態
    Liquid
  • 備考

    1. Chen G, Cizeau J, Vande Velde C, et al. Nix and Nip3 form a subfamily of pro-apoptoticmitochondrial proteins. J Biol Chem (1999) 274(1):7-10.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

関連情報

  • 別名
    • Adenovirus E1B19k binding protein B5
    • Adenovirus E1B19K-binding protein B5
    • BCL2/adenovirus E1B 19 kd protein interacting protein 3a
    • BCL2/adenovirus E1B 19 kDa protein interacting protein 3A
    • BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
    • BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A
    • BCL2/adenovirus E1B 19kDa interacting protein 3 like
    • BNI3L_HUMAN
    • BNIP3a
    • BNIP3H
    • BNIP3L
    • BNIP3L protein
    • NIP3 like protein X
    • NIP3-like protein X
    • NIP3L
    • NIX
    see all
  • 機能
    Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. May function as a tumor suppressor. Inhibits apoptosis induced by BNIP3.
  • 配列類似性
    Belongs to the NIP3 family.
  • 翻訳後修飾
    Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.
  • 細胞内局在
    Nucleus envelope. Endoplasmic reticulum. Mitochondrion. Membrane.
  • Information by UniProt

参考文献

ab8431 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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