Anti-Blooms Syndrome Protein Blm 抗体 (ab70309)

製品の概要

• 製品名
  Anti-Blooms Syndrome Protein Blm antibody
  Blooms Syndrome Protein Blm 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to Blooms Syndrome Protein Blm
• アプリケーション
  適用あり: IPmore details
  適用なし: WB
• 種交差性
  交差種: Mouse, Human
  
• 免疫原

  Synthetic peptide corresponding to a region between residues 50 and 100 of mouse Blooms Syndrome Protein Blm. ( NP_031576.2 )

• ポジティブ･コントロール
  • NIH3T3 whole cell lysate.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファー
  Preservative: 0.09% Sodium Azide
  Constituents: 8mM PBS, 60mM Citrate, 150mM Tris, pH 7-8
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • Homologous Recomb.

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • NIH 3T3 whole cell lysate (ab7179)

アプリケーション

ターゲット情報

• 機能
  Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.
• 関連疾患
  Defects in BLM are the cause of Bloom syndrome (BLM) [MIM:210900]. BLM is an autosomal recessive disorder characterized by proportionate pre- and postnatal growth deficiency, sun-sensitive telangiectatic hypo- and hyperpigmented skin, predisposition to malignancy, and chromosomal instability.
• 配列類似性
  Belongs to the helicase family. RecQ subfamily.
  Contains 1 helicase ATP-binding domain.
  Contains 1 helicase C-terminal domain.
  Contains 1 HRDC domain.
• 翻訳後修飾
  Phosphorylated in response to DNA damage. Phosphorylation requires the FANCA-FANCC-FANCE-FANCF-FANCG protein complex, as well as the presence of RMI1.
• 細胞内局在
  Nucleus.

• Target information above from: UniProt accession P54132 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 641 Human
  • Entrez Gene: 12144 Mouse
  • Omim: 604610 Human
  • SwissProt: P54132 Human
  • SwissProt: O88700 Mouse
  • Unigene: 725208 Human
  • Unigene: 12932 Mouse
• 別名
  • Blm antibody
  • BLM_HUMAN antibody
  • Bloom syndrome antibody

  • Bloom syndrome protein antibody
  • Bloom syndrome RecQ helicase like antibody
  • BS antibody
  • DNA helicase antibody
  • DNA helicase RecQ like type 2 antibody
  • MGC126616 antibody
  • MGC131618 antibody
  • MGC131620 antibody
  • RECQ 2 antibody
  • RECQ like antibody
  • RecQ like type 2 antibody
  • RecQ protein like 3 antibody
  • RecQ protein-like 3 antibody
  • RecQ-like type 2 antibody
  • RecQ2 antibody
  • RECQL 2 antibody
  • RECQL 3 antibody
  • RECQL2 antibody
  • RECQL3 antibody
  • type 2 antibody

  see all

プロトコール

• Immunoprecipitation protocols