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Src ~ 注目ターゲットのおすすめ製品


ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

Src Hu, Ms, RatFlow Cyt, ICC/IF, IHC-P, WB1 ab109381
Src Hu, Ms, RatIHC-P, WB ab133283
Src (pY418) Rat, HuWB ab133460
Src (pY419) Hu, Ms, RatDot, Flow Cyt, WB ab185617
Src (pY529)Hu, Ms, RatDot, ICC/IF, IP, WB31 ab32078
SRC Family (pY418) Ms, Hu, RatFlow Cyt, ICC/IF, WB121 ab40660
Src Alexa Fluor® 488 HuICC/IF ab205752
SrcAlexa Fluor® 647 HuICC/IF ab205753

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

SrcMs-M
Hu, Ms, RatFlow Cyt, IP, WB24 ab16885
SrcRb-PHu, Ms, Rat, PigELISA, ICC/IF, IHC-P, WB36 ab47405
Src (pY418)Rb-PHu, Ms, ChkIHC-FoFr, WB121 ab4816
Src (pY418)
Alexa Fluor® 488
Rb-P Ms, Chk, Hu, DogICC/IF ab200824
Src (pY529)Rb-PHu, Ms, Rat, ChkIHC-Fr, WB1 ab4817
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

Src protein (Active) HuFuncS, SDS-PAGE, WBab79635
Src protein (Active) (Recombinant)FuncS, SDS-PAGEab60884
Src protein (Active) (Recombinant)HuFuncS, SDS-PAGEab51424
Src protein (Active) (Recombinant)HuFuncS, SDS-PAGEab79634
Src protein (Recombinant)HuSDS-PAGEab90186
Src peptideHuBL, ELISAab42782
Src (pY529) peptideBLab179556

Src について

Function
機能
Non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins, by PTK2B, it phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling.
Tissue specificity
組織特異性
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily.
  • Tyr protein kinase family.
  • SRC subfamily.
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
Post-translational modifications
翻訳後修飾
Dephosphorylated at Tyr-530 by PTPRJ (By similarity). Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. Dephosphorylated by PTPRJ at Tyr-419. Normally maintained in an inactive conformation with the SH2 domain engaged with Tyr-530, the SH3 domain engaged with the SH2-kinase linker, and Tyr-419 dephosphorylated. Dephosphorylation of Tyr-530 as a result of protein tyrosine phosphatase (PTP) action disrupts the intramolecular interaction between the SH2 domain and Tyr-530, Tyr-419 can then become autophosphorylated, resulting in SRC activation. Phosphorylation of Tyr-530 by CSK allows this interaction to reform, resulting in SRC inactivation. S-nitrosylation is important for activation of its kinase activity.
Cellular localization
細胞内局在性
Cell membrane. Mitochondrion inner membrane.

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