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p21 ~ 注目ターゲットのおすすめ製品


抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

p21 Ms WB, IHC-P, Flow Cyt, IP, ICC/IF2 1ab188224
p21
Ms, Rat, HuWB198 ab109199
p21
HuFlow Cyt, ICC/IF, IHC-P, IP, WB174 ab109520
p21
BSA and Azide free

Hu ICC/IF, IP, WB, IHC-P, Flow Cyt9ab218311
p21
BSA and Azide free

Ms, Rat, Hu, AGMKWBab215971
p21Ms-M
Hu, RatFlow Cyt, IHC-P, IP, WB31 ab80633
p21Ms-MHu, Rat, MkELISA, ICC/IF, IHC-Fr, WB4 ab7903
p21Rb-PHuDot, IHC-P, WB2 ab135553
p21Ms-M Hu, RecFragICC/IF, IHC-P, WB1 ab54562
p21Rb-PHuELISA, IHC-P, WB1 ab47300
p21Ms-MHu, RbFlow Cyt, sELISA, WB1 ab118
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

p21 protein (Recombinant )HuFuncS, SDS-PAGE, WBab56278
p21 protein (Recombinant )HuSDS-PAGEab134524
タンパク質・ペプチド一覧

キット

製品名

交差種

容量

製品番号

p21 ELISA KitHu1x96testsab214658
p21 ELISA Kit (CDKN1A) Ms1x96testsab205576
p21 Matched Antibody Pair KitHu2x96tests
10x96tests
ab212063
p21 Matched Antibody Pair KitMs2x96tests
10x96tests
ab212072
Apoptosis Antibody Array (43 Targets)Hu1x2memb
1x4memb
1x8memb
ab134001

生理活性物質

製品名

解説

製品番号

IPA 3Group I, p21-activated kinase (PAK) inhibitorab141014

p21について

Function
機能
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1.
Tissue specificity
組織特異性
Expressed in all adult human tissues, with 5-fold lower levels observed in the brain.
Sequence similarities
配列類似性
Belongs to the CDI family.
Post-translational modifications
翻訳後修飾
Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA. Phosphorylation at Ser-114 by GSK3-beta enhances ubiquitination by the DCX(DTL) complex. Ubiquitinated by MKRN1; leading to polyubiquitination and 26S proteasome-dependent degradation. Ubiquitinated by the DCX(DTL) complex, also named CRL4(CDT2) complex, leading to its degradation during S phase or following UV irradiation. Ubiquitination by the DCX(DTL) complex is essential to control replication licensing and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation.
Cellular localization
細胞内局在
Cytoplasm. Nucleus.

関連リンク


注目ターゲット

Cancer
ポータル

p53 抗体と
キット

Cyclin 抗体と
タンパク質

Cdk2 抗体と
タンパク質

p21 リソース

p21 の研究に
有用な製品

p21 と
アポトーシス

p21 と DNA 結合
タンパク質

注目の文献:
がんにおける
p21 の関与

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