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Ubiquitin ~ 注目ターゲットのおすすめ製品


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UbiquitinHu, Ms, RatFlow Cyt, ICC/IF, IHC-P, WB51 ab134953
Ubiquitin (linkage-specific K48) Hu, Ms, RatFlow Cyt, ICC/IF, WB86 ab140601
Ubiquitin (linkage-specific K63)ICC/IF, IHC-P, WB43 ab179434
Ubiquitin (linkage-specific K27) Hu, Ms, RatFlow Cyt, IHC-P, WB ab181537
Ubiquitin (linkage-specific K63) Alexa Fluor® 647 HuFlow Cyt, ICC/IF ab192489
Ubiquitin (linkage-specific K48) Alexa Fluor® 488 HuICC/IF ab204274
Ubiquitin Alexa Fluor® 488 HuICC/IF ab205467
Ubiquitin Alexa Fluor® 647 HuICC/IF ab205468

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UbiquitinRb-PHu, Ms, Rat, AGMkICC/IF, IHC-FoFr, IHC-P, IP, WB39 29ab7780
UbiquitinMs-M Ms, Chk, Cow, Hu, At, Ce, Dm, DCV, RatELISA, ICC/IF, IHC-Fr, IHC-P, WB257ab7254
Ubiquitin (HRP)Ms-M n/aIHC-Fr, IHC-P, WB ab191809
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Ubiquitin K33 only protein (Recombinant / Active )HuFuncS, MS, Other, SDS-PAGE, WBab157076
Ubiquitin K48 only protein (Recombinant / Active )HuFuncS, MS, Other, SDS-PAGE, WBab157048
Ubiquitin K63 only protein (Recombinant / Active )HuFuncS, MS, Other, SDS-PAGE, WBab157056
Tetra-ubiquitin (linkage-specific K63) protein (biotinylated /Recombinant / Active)HuFuncS, SDS-PAGEab189683
Ubiquitin (mutated K33) protein (Recombinant / Chemical Free)HuConjugation, SDS-PAGEab80742
Poly-ubiquitin (linkage-specific K48) protein (Recombinant / Active )HuFuncS, SDS-PAGEab189706
Tetra-ubiquitin (linkage-specific K11) protein (Recombinant)HuHPLC, WBab180028
Triubiquitin (linkage-specific K48) protein (Recombinant)HuMS, SDS-PAGE, WBab166765
Di-ubiquitin (linkage-specific K11) protein (Recombinant)HuSDS-PAGEab206451
Di-ubiquitin (linkage-specific K48) (mutated K48 R) protein (Recombinant)HuFuncS, SDS-PAGEab207972
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E2-Ubiquitin Conjugation Kit50testab139472
Ubiquitylation Assay Kit20testab139467
Ubiquitylation Assay Kit (HeLa lysate-based)20testab139471
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NSC-632839Nonselective ubiquitin isopeptidase inhibitorab144599
SMER3 Potent and selective ubiquitin C-terminal hydrolase L1 inhibitorab144596
BML-282 Potent and selective ubiquitin C-terminal hydrolase L1 inhibitorab144529
TCIDPotent and selective ubiquitin C-terminal hydrolase-L3 inhibitorab144528
PYR-41 Ubiquitin-activating enzyme (E1) inhibitorab141469
生理活性物質一覧

Ubiquitin について

Relevance
関連性
Function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. Similarity: Belongs to the ubiquitin family. Contains 3 ubiquitin-like domains.
Cellular localization
細胞内局在性
Cell Membrane, Cytoplasmic and Nuclear

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PI 3 Kinase ~ 注目ターゲットのおすすめ製品


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PI 3 Kinase catalytic subunit alpha Hu, MsICC/IF, IP, WB51 ab40776
PI 3 Kinase catalytic subunit alpha
Alexa Fluor® 488
HuICC/IF ab202671
PI 3 Kinase p55 gamma Hu, Ms, RatICC/IF, IHC-P, WB1 ab186612
PI 3 Kinase p85 alpha Hu, Ms, Rat WB, ICC/IF, Flow Cyt, IP ab191606
PI 3 Kinase p85 beta Hu, RatFlow Cyt, ICC/IF, IHC-P, IP, WB ab180967
PI 3 Kinase p110 betaHu, Ms, RatFlow Cyt, ICC/IF, IHC-P, WB3 ab151549
PI 3 Kinase p110 beta
Alexa Fluor® 488
HuICC/IF ab202666
PI 3 Kinase p110 delta Hu, Ms, RatICC, WB2 ab109006
PI 3 Kinase p110 delta (HRP) Ms, HuWB ab200773
PI 3 Kinase regulatory subunit 4Hu, Ms, RatFlow Cyt, ICC/IF, IHC-P, WB ab124817

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PI 3 Kinase catalytic subunit alphaMs-MHuELISA, Flow Cyt, ICC/IF, WB ab126819
PI 3 Kinase p85 alpha Ms-M HuELISA, ICC, ICC/IF, IHC-P, WB94 ab86714
PI 3 Kinase p85 alphaMs-M Hu, MsFlow Cyt, ICC/IF, IHC-P, WB2 ab189403
PI 3 Kinase p85 alpha (pY607)Rb-P Ms, Rat, HuWB8 ab182651
PI 3 Kinase p85 betaMs-M Hu, MkIHC-Fr, IP, WB4 ab28356
PI 3 Kinase p110 deltaRb-P Hu, MsELISA, ICC, ICC/IF, IP, WB93 ab1678
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PI 3 Kinase catalytic subunit gamma protein (Active / Recombinant)HuFuncS, SDS-PAGE, WBab125538
PI 3 Kinase catalytic subunit alpha protein (Recombinant)HuELISA, WBab159127
PI 3 Kinase p55 gamma protein (Recombinant)HuSDS-PAGE, WBab127108
PI 3 Kinase p85 beta protein (Recombinant)HuSDS-PAGE, WBab125568
PI 3 Kinase p110 alpha + PI 3 kinase p85 alpha protein (Active / Recombinant)HuFuncS, SDS-PAGE, WBab91093
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PI3K p85 In-Cell ELISA Kit Total + Phospho-tyrosineMs, Rat, Hu1×96tests
5×96tests
ab207484
PI3K p85 In-Cell ELISA Kit Total + Phospho-tyrosine (Chemiluminescent)Ms, Rat, Hu1×96tests
5×96tests
ab207485
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製品名

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3-Methyladenine Selective PI3K inhibitorab120841
LY 303511 PI3-kinase inhibitor. Kv channel blocker.ab145193
Viridiol Steroid antibiotic agent. PI 3-kinase inhibitor.ab144384
CAY10626 Potent PI3Kα/mTOR inhibitorab120903
LY 294002 PI3-kinase inhibitorab120243
LY 303511 dihydrochloride Negative control for LY 294002 (ab120243)ab120956
生理活性物質一覧

PI 3 Kinase について

PI 3 Kinase catalytic subunit alpha
Function
機能
Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
Involvement in disease
関連疾患
Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. Defects in PIK3CA are a cause of susceptibility to breast cancer (BC) [MIM:114480]. A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. Defects in PIK3CA are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. Ovarian cancer common malignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Defects in PIK3CA may underlie hepatocellular carcinoma (HCC) [MIM:114550]. Defects in PIK3CA are a cause of keratosis seborrheic (KERSEB) [MIM:182000]. A common benign skin tumor. Seborrheic keratoses usually begin with the appearance of one or more sharply defined, light brown, flat macules. The lesions may be sparse or numerous. As they initially grow, they develop a velvety to finely verrucous surface, followed by an uneven warty surface with multiple plugged follicles and a dull or lackluster appearance.
Sequence similarities
配列類似性
  • Belongs to the PI3/PI4-kinase family.
  • Contains 1 C2 domain.
  • Contains 1 PI3K/PI4K domain.

PI 3 Kinase p55 gamma
Function
機能
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
Tissue specificity
組織特異性
Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.
Sequence similarities
配列類似性
  • Belongs to the PI3K p85 subunit family.
  • Contains 2 SH2 domains.

PI 3 Kinase p85 alpha
Function
機能
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
Tissue specificity
組織特異性
Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
Sequence similarities
配列類似性
  • Belongs to the PI3K p85 subunit family.
  • Contains 1 Rho-GAP domain.
  • Contains 2 SH2 domains.
  • Contains 1 SH3 domain.
Post-translational modifications
翻訳後修飾
Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation. Phosphorylated. Dephosphorylated by PTPRJ.

PI 3 Kinase p85 beta
Function
機能
Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement.
Involvement in disease
関連疾患
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1
Sequence similarities
配列類似性
  • Belongs to the PI3K p85 subunit family.
  • Contains 1 Rho-GAP domain.
  • Contains 2 SH2 domains.
  • Contains 1 SH3 domain.
Post-translational modifications
翻訳後修飾
Phosphorylated in response to signaling from activated receptor-type protein kinases (PubMed:19690332, PubMed:20068231). Dephosphorylated by PTPRJ (PubMed:18348712). Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination (PubMed:23604317). Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2.

PI3 Kinase p110 beta
Function
機能
Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
Tissue specificity
組織特異性
Expressed ubiquitously.
Sequence similarities
配列類似性
  • Belongs to the PI3/PI4-kinase family.
  • Contains 1 PI3K/PI4K domain.

PI 3 Kinase p110 delta
Tissue specificity
組織特異性
Expressed predominantly in leukocytes.
Sequence similarities
配列類似性
  • Belongs to the PI3/PI4-kinase family.
  • Contains 1 PI3K/PI4K domain.
Post-translational modifications
翻訳後修飾
Autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity.

PI 3 Kinase regulatory subunit 4
Function
機能
Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway.
Tissue specificity
組織特異性
Ubiquitously expressed.
Sequence similarities
配列類似性
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
  • Contains 3 HEAT repeats.
  • Contains 1 protein kinase domain.
  • Contains 7 WD repeats.
Post-translational modifications
翻訳後修飾
Myristoylated.Probably autophosphorylated.

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Rho ~ 注目ターゲットのおすすめ製品


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RhoHu, Ms, RatICC/IF, IHC-P, WB23 ab40673
Rho
Alexa Fluor® 488
HuICC/IF ab203324
RhoA Hu, Ms, RatFlow Cyt, ICC/IF, WB2 ab187027
Rho A + B + C Hu, Ms, RatFlow Cyt, ICC/IF, IHC-P, WB ab188103
RhoGDIHu, Ms, RatICC, IHC-P, WB11 ab133248
RhoGDI (HRP) Ms, HuIHC-P, WB ab200183

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RhoAMs-MHuELISA, Flow Cyt, ICC/IF, IHC-P, WB118 ab54835
Rho A + B + CMs-M Ms, Rat, HuICC/IF, IP, WB ab175328
RHOCMs-MHu, RatFlow Cyt, WB1 ab54837
RhoGDIMs-MHu, Ms, MkFlow Cyt, ICC/IF, WB2 ab135252
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Rho GTPase-activating protein 24 protein (Recombinant )HuELISA, WBab164402
RHOG protein (Recombinant )HuMS, SDS-PAGEab128454
RHOB protein (Recombinant )HuMS, SDS-PAGEab107139
RhoGDI protein (Recombinant )HuELISA, SDS-PAGE, WBab132108
RhoA protein (Recombinant )HuSDS-PAGE, WBab101594
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RhoA G17A Agarose Beads (Active Rho-GEF)400ugab211183
RhoA Activation Assay Kit Hu, Ms, Rat5test
20test
ab211164
RhoB Activation Assay Kit Hu, Ms, Rat5test
20test
ab211165
RhoC Activation Assay Kit Hu, Ms, Rat5test
20test
ab211166
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Thiazovivin (DMSO solution)Rho kinase inhibitor. Thiazovivin (ab142081) solution. Reverses Ang II-induced MYPT1 and MLC phosphorylation. Enhances fibroblast reprogramming efficiency during pluripotent stem cell formation.ab146618
N-Boc-Y-27632Protected Y-27632, a Rho kinase (ROCK) inhibitorab143784
HA 1100 hydrochloride (Hydroxyfasudil)Selective, ATP-competitive, reversible Rho-kinase inhibitorab145524
生理活性物質一覧

Rho について

Rho
Function
機能
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Sequence similarities
配列類似性
  • Belongs to the small GTPase superfamily. Rho family.
Post-translational modifications
翻訳後修飾
Substrate for botulinum ADP-ribosyltransferase. Cleaved by yopT protease when the cell is infected by some Yersinia pathogens. This removes the lipid attachment, and leads to its displacement from plasma membrane and to subsequent cytoskeleton cleavage. AMPylation at Tyr-34 and Thr-37 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo. Phosphorylation by PRKG1 at Ser-188 inactivates RHOA signaling. Ubiquitinated by the BCR(BACURD1) and BCR(BACURD2) E3 ubiquitin ligase complexes, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.
Cellular localization
細胞内局在性
Cell membrane. Cytoplasm > cytoskeleton. Cleavage furrow. Cytoplasm > cell cortex. Midbody. Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in a activated form and in a myosin- and actin-independent manner.

RhoA
Function
機能
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP.
Sequence similarities
配列類似性
  • Belongs to the small GTPase superfamily. Rho family.
Post-translational modifications
翻訳後修飾
Substrate for botulinum ADP-ribosyltransferase. Cleaved by yopT protease when the cell is infected by some Yersinia pathogens. This removes the lipid attachment, and leads to its displacement from plasma membrane and to subsequent cytoskeleton cleavage. AMPylation at Tyr-34 and Thr-37 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo. Ubiquitinated by the BCR(BACURD1) and BCR(BACURD2) E3 ubiquitin ligase complexes, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.
Cellular localization
細胞内局在性
Cell membrane. Cytoplasm > cytoskeleton.

RhoC
Function
機能
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.
Sequence similarities
配列類似性
  • Belongs to the small GTPase superfamily. Rho family.
Cellular localization
細胞内局在性
Cell membrane.

RhoGDI
Function
機能
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
Sequence similarities
配列類似性
  • Belongs to the Rho GDI family.
Cellular localization
細胞内局在性
Cytoplasm.

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バイオ関連ニュース17.8.17

GST ~ 注目ターゲットのおすすめ製品


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GSTICC, IP, WB ab111947
GST3 / GST pi Hu, Ms, RatICC/IF, IHC-P, WB1 ab138491
GST3 / GST pi (HRP) HuIHC-P, WB ab202930
GST3 / GST pi
Alexa Fluor® 488
HuICC/IF ab203152

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GSTRb-PN/AChIP, ELISA, ICC, IP, WB105ab19256
GSTMs-MN/ADot, ELISA, ICC, ICC/IF, IP, WB ab18183
GSTMs-M n/aIP, WB92ab92
GSTRb-PELISA, ICC/IF, IP, WB262 ab9085
GST (HRP)Rb-P n/aELISA, WB153 ab3416
GST3 / GST piRb-PHu, Ms, RatICC/IF, IHC-P, WB14ab153949
GST3 / GST piGoat-PHu, Ms, Rat, Hm, RbICC/IF, IHC-P, IP, WB12 ab53943
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GST protein (Active) S. japonicum FuncS, SDS-PAGEab168026
GST protein(Recombinant)HuFuncS, SDS-PAGEab81793
GST protein(Recombinant)S. japonicumSDS-PAGEab70456
GST3 / GST pi protein(Recombinant)MsMS, SDS-PAGEab206784
GST3 / GST pi protein(Recombinant)HuSDS-PAGE, WBab86703
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GST Activity Assay Kit (Colorimetric) Hu100testab65326
GST Activity Assay Kit (Fluorometric)100testab65325
GST 6XHis-tag ELISA Kit1×96testsab128573
GST tag ELISA Kit1×96testsab126581
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製品名

解説

製品番号

16-OxokahweolSynthetic kahweol derivative. Glutathione S-transferase inducer.ab143677
S-HexylglutathioneGlutathione S-transferase inhibitorab143631
Ethacrynic acidPotent Glutathione S-transferase (GST) inhibitorab141399

GST について

GST
Relevance
関連性
GST (Glutathione S-Transferase) is a 26kDa protein encoded by the parasitic helminth Schistosoma japonicum and widely used in the pGEX family of GST plasmid expression vectors as a fusion protein with foreign proteins.

GST3 / GST pi
Function
機能
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Sequence similarities
配列類似性
  • Belongs to the GST superfamily. Pi family.
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.

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Phospholipase C beta 1 Hu, Ms, RatIHC-P, IP, WB ab182368
Phospholipase C beta 3 HuIHC-P, WB ab124735
Phospholipase C beta 1+Phospholipase C beta 3 Hu, Ms, RatIHC-P, IP, WB ab184743
Phospholipase C gamma 1 Hu, Ms, RatICC, IP, WB ab76155
Phospholipase C gamma 1
(HRP)
HuWB ab195861
Phospholipase C gamma 1
(pY783)
HuICC, WB ab76031
Phospholipase C gamma 1 (pY1253) HuICC, WB ab81284
PLCG 2 HuFlow Cyt, IHC-P, IP, WB ab133522
PLCG 2
Alexa Fluor® 488
Hu ICC/IF ab201241

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Phospholipase C beta 1Rb-P Ms, Rat, HuICC/IF, IHC-P, WB ab185724
Phospholipase C beta 3Rb-PHuELISA, IHC-P, WB22 ab52199
Phospholipase C beta 3 (pS537)Rb-P Ms, HuELISA, ICC/IF, IHC-P, WB3 ab73998
Phospholipase C gamma 1Ms-M
Hu, Ms, RatELISA, Flow Cyt, IP, WB31 ab16955
Phospholipase C gamma 1Ms-M
HuELISA, Flow Cyt, ICC/IF, IP, WB13 ab41433
Phospholipase C gamma 1Rb-P
HuICC/IF, WB ab107455
PLCG 2 Ms-M
HuICC, WB ab201645
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製品名

由来

適用・アプリケーション

製品番号

Phospholipase C beta 1 protein (Recombinant )HuELISA, WBab153213
Phospholipase C gamma 1 protein (Recombinant )HuELISA, SDS-PAGE, WBab112339
Phospholipase C gamma 1 (pY775) peptideHuBL, ELISAab42756
タンパク質・ペプチド一覧

生理活性物質

製品名

解説

製品番号

U 73122Standard phospholipase C (PLC) inhibitorab120998
ManoalideIrreversible phospholipase C (PLC) inhibitorab141554
L-alpha-PhosphatidylinositolPhospholipase C substrateab146179
生理活性物質一覧

PLC について

Phospholipase C beta 1
Function
機能
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Involvement in disease
関連疾患
Epileptic encephalopathy, early infantile, 12
Sequence similarities
配列類似性
  • Contains 1 C2 domain.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
Cellular localization
細胞内局在性
Nucleus membrane. Cytoplasm. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.

Phospholipase C beta 3
Function
機能
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Sequence similarities
配列類似性
  • Contains 1 C2 domain.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
Cellular localization
細胞内局在性
Membrane.

Phospholipase C gamma
Function
機能
Plays a role in actin reorganization and cell migration. The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
Sequence similarities
配列類似性
  • Contains 1 C2 domain.
  • Contains 1 EF-hand domain.
  • Contains 2 PH domains.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
  • Contains 2 SH2 domains.
  • Contains 1 SH3 domain.
Post-translational modifications
翻訳後修飾
The receptor-mediated activation of PLC-gamma-1 and PLC-gamma-2 involves their phosphorylation by tyrosine kinases in response to ligation of a variety of growth factor receptors and immune system receptors. May be dephosphorylated by PTPRJ. Ubiquitinated by CBLB in activated T-cells.
Cellular localization
細胞内局在性
Cell projection > lamellipodium. Cell projection > ruffle. Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.

PLCG 2
Function
機能
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
Sequence similarities
配列類似性
  • Contains 1 C2 domain.
  • Contains 1 PH domain.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
  • Contains 2 SH2 domains.
  • Contains 1 SH3 domain.
Post-translational modifications
翻訳後修飾
Phosphorylated on tyrosine residues; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Increases phospholipase activity.
Cellular localization
細胞内局在性

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Neuroscience
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注目ターゲット

代謝型グルタミン酸受容体 mGluR

CREB ~ 注目ターゲットのおすすめ製品


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製品番号

CREB Hu, Ms, RatFlow Cyt, ICC/IF, IHC-P, IP, WB143 ab32515
CREB (pS133)Hu, Ms, RatICC/IF, IHC-P, IP, WB1513 ab32096
CREB (HRP) HuIHC-P ab194313
CREB
Alexa Fluor® 647
HuFlow Cyt, ICC/IF ab194312
CREB (pS133)
Alexa Fluor® 405
HuICC/IF ab210124

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数 評価

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CREBMs-M
ELISA, ICC/IF, IHC-P, IP, WB ab178322
CREBRb-P Ms, Rat, HuChIP, ELISA, ICC/IF, IHC-P, WB53 ab31387
CREB (pS129+S133)Rb-PHu, MsWB22 ab10564
CREB FITCRb-MFlow Cyt ab175642
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タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

CREB protein RatFuncSab43602
CREB peptideFuncS, HPLCab204856
CREB proteinHuSDS-PAGEab176930
CREB (pS133) peptideHuBLab38313
タンパク質・ペプチド一覧

キット

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容量

製品番号

CREB1 ELISA Kit Hu, Ms1×96testsab176639
CREB1 pS133 + CREB1 ELISA Kit Ms, Hu1×96testsab176659
CREB1 pS133 ELISA Kit Hu, Ms1×96testsab176638
Total CREB Transcription Factor Assay KitMs, Rat, Hu, Mkey5×96tests
1×96tests
ab207201
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MAPK Phosphorylation 抗体 Array

Targets: Akt (pS473), CREB (pS133), ERK1 (pT202/Y204)/ERK2 (pT185/Y187), GSK3a (pS21), GSK3b (pS9), HSP27 (pS82), JNK (pT183), MEK (pS217/221), MKK3 (pS189), MKK6 (pS207), MSK2 (pS360), mTOR (pS2448), p38 (pT180/Y182), p53 (pS15), P70S6K (pT421/S424), RSK1 (pS380), RSK2 (pS386).

Hu2 Membrane
4 Membrane
8 Membrane
ab211061

CREB について

Function
機能
This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.
Involvement in disease
関連疾患
Defects in CREB1 may be a cause of angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=A chromosomal aberration involving CREB1 is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type.
Sequence similarities
配列類似性
  • Belongs to the bZIP family.
  • Contains 1 bZIP domain.
  • Contains 1 KID (kinase-inducible) domain.
Post-translational modifications
翻訳後修飾
Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. Sumoylated by SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.
Cellular localization
細胞内局在性
Nucleus.

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注目ターゲット

Epigenetics
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MMP ~ 注目ターゲットのおすすめ製品


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MMP1 HuFlow Cyt, ICC, IHC-Fr, IHC-P, WB123 ab52631
MMP2Hu, Ms, RatFlow Cyt, ICC/IF, WB16 1ab92536
MMP3Hu, Ms, RatICC/IF, IHC-P, WB233 ab52915
MMP7 HuIHC-P, WB2 ab205525
MMP8Hu, Ms, RatFlow Cyt, ICC, IHC-P, IP, WB103 ab81286
MMP9 Rat, HuFlow Cyt, ICC/IF, IHC-P, WB82 6ab76003
MMP9 Hu, DogIHC-Fr, IHC-P, WB105ab137867
MMP9 (HRP) HuIHC-P, WB ab194316
MMP12Hu, Ms, RatIP, WB14 ab52897
MMP14 Ms, Rat, HuFlow Cyt, ICC/IF, IHC-P, IP, WB3113 ab51074
MMP14 (HRP) HuIHC-P ab194242
MMP17Hu, Ms, RatICC/IF, IHC-FoFr, IHC-P, WB52 ab51075

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数 評価

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MMP1Rb-PHu, Dog, HrsICC/IF, IHC-Fr, IHC-P, WB106 ab38929
MMP2Rb-PHu, Ms, Rat, ChkFlow Cyt, ICC/IF, IHC-Fr, IHC-P, WB5013 ab37150
MMP2Ms-MHu, Ms, RatIHC-FoFr, IHC-P, WB184 ab86607
MMP3Rb-PHu, Ms, RatELISA, ICC/IF, IHC-P, WB156ab53015
MMP7Rb-PHu, MsELISA, ICC/IF, IHC-Fr, IHC-P, IP, WB92 ab5706
MMP9Rb-PHu, Ms, Rat, DogELISA, ICC, ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, IP, WB132 42ab38898
MMP10Rb-PHu, Ms, RatELISA, Flow Cyt, ICC/IF, IHC-Fr1 1ab59437
MMP12Rb-PHuICC/IF, IHC-P, WB1 ab137444
MMP14Rb-PHu, Ms, PigELISA, ICC/IF, IHC-P, IP, WB193 ab38971
MMP14Ms-MHu, MsELISA, Flow Cyt, ICC/IF, IHC-Fr, Inhib, IP, WB5 ab78738
MMP19Rb-PHuELISA, IHC-P, WB3 ab53146

タンパク質・ペプチド

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由来

適用・アプリケーション

文献数

製品番号

MMP1 protein (Active)HuFuncS, SDS-PAGEab134442
MMP1 proteinHuELISA, SDS-PAGE, WBab39297
MMP2 protein (Recombinant / Active)HuFuncS, SDS-PAGE1ab174022
MMP3 protein (Recombinant / Active)HuFuncS, SDS-PAGE, WB1ab96555
MMP3 proteinHuSDS-PAGE, WB1ab39306
MMP9 protein (proenzyme / Active)HuFuncS, SDS-PAGE, WB1ab157344
MMP9 protein (Active)HuFuncS, SDS-PAGE, WB1ab168863
MMP9 protein (Recombinant)MsFuncS, SDS-PAGE, WB2ab39309
MMP11 protein (Recombinant)HuELISA, MS, SDS-PAGE, WB1ab92861
MMP12 protein (Recombinant)HuELISA, SDS-PAGE, WBab80209
MMP13 protein (Recombinant / Active)HuFuncS, SDS-PAGEab134452
MMP14 protein (Recombinant / Active)HuFuncS, SDS-PAGEab168081
MMP24 protein (Recombinant / Active)HuFuncS, SDS-PAGEab157081
タンパク質・ペプチド一覧

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製品番号

MMP14 ELISA Kit Hu1×96testsab197747
MMP1 ELISA Kit Hu1×96testsab215083
MMP3 ELISA Kit Hu1×96testsab189572
MMP3 ELISA Kit Ms1×96testsab203363
MMP8 ELISA Kit Ms1×96testsab206982
MMP8 ELISA Kit Hu1×96testsab219050
MMP13 ELISA Kit Rat, Rb, Cow, Hu, Pig1×96testsab221839
MMP-3 Activity Assay Kit (Fluorometric)Mamm100testab118972
MMP1 Inhibitor Screening Assay Kit (Colorimetric)1×96testsab139443
MMP7 Inhibitor Screening Assay Kit (Colorimetric)1×96testsab139444
MMP9 Inhibitor Screening Assay Kit (Colorimetric)1×96testsab139448
MMP2 Inhibitor Screening Assay Kit (Colorimetric)1×96testsab139446
MMP8 Multiplex Immunoassay Kit Ms1×96tests ab221531
MMP8 Multiplex Immunoassay Kit Hu1×96testsab219031
MMP13 Multiplex Immunoassay Kit Hu1×96testsab219030
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MMP Antibody Array - Membrane (10 Targets)
Targets:MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-10, MMP-13, TIMP-1, TIMP-2, TIMP-4
Hu1×4Membranes
1×8Membranes
ab134004
MMP Antibody Array (10 Targets) - Quantitative
Targets:MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-10, MMP-13, TIMP-1, TIMP-2, TIMP-4.
Hu8test
22test
50test
ab197453
Angiogenesis Antibody Array - Membrane (23 targets)
Targets: Angiopoietin 1, Angiopoietin 2, Angiostatin, Endostatin, G-CSF, GM-CSF, I-309, IL-10, IL-1 alpha, IL-1 beta, IL-2, IL-4, I-TAC, MCP-3, MCP-4, MMP-1, MMP-9, PECAM-1, Tie-2, TNF alpha, uPAR, VEGFR2, VEGFR3
Hu1×4Membranes
1×8Membranes
ab169808
Cytokine Array – Rat Cytokine Antibody Array (Membrane, 34 Targets)
Targets: Activin A, Agrin, Thymus Chemokine-1, B7-2/CD86, CINC-1, CINC-2alpha, CINC-3, CNTF, Fas Ligand, Fractalkine, GM-CSF, ICAM-1, IFN-gamma, IL-1 R6, IL-10, IL-13, IL-1alpha, IL-1beta, IL-2, IL-4, IL-6, Leptin, LIX, L-Selectin, MCP-1, MIP-3alpha, MMP-8, beta-NGF, PDGF-AA, Prolactin R, RAGE, TIMP-1, TNF-alpha, VEGF.
Rat1×4Membranes
1×8Membranes
ab133992
Cytokine Antibody Array - Membrane (34 Targets)
Targets: bFGF, DPPIV/CD26, Dtk, E-Selectin, Fc gamma RIIB, Flt-3 Ligand, GITR, HGF R, ICAM-1, IGFBP-2, IGF-1, IGF-2, IL-15, IL-17B R, IL-7, I-TAC, Lungkine, MDC, MMP-2, MMP-3, Osteopontin, Osteoprotegerin, Pro-MMP-9, Resistin, Shh-N, Thymus CK-1, TIMP-2, TRANCE, TROY, TSLP, VEGFR1, VEGFR2, VEGFR3, VEGF-D
Ms1×2Membranes
1×4Membranes
1×8Membranes
ab169810
Cytokine Antibody Array - Membrane (51 Targets)
Targets: Adipsin, BCAM, CD30, CD40, Fc gamma RIIB/C, Ferritin, FLRG, Follistatin, Furin, Galectin-7, GDF-15, Growth Hormone, IL-10 R alpha, IL-22, IL-28A, IL-29, IL-31, Insulin, Luteinizing hormone, LIMPII, LYVE-1, Marapsin, MICA, MICB, MMP-2, MMP-7, MMP-8, MMP-10, NCAM-1, Nidogen-1, NrCAM, NRG1-beta 1, Osteopontin, PAI-I, Platelet factor 4, PSA-total, RAGE, RANK, Resistin, SAA, Siglec-9, TACE, TIM-1, TRAIL R2, Trappin-2, TREM-1, TSH, TSLP, VCAM-1, VEGF-C, XEDAR
Hu1×2Membranes
1×4Membranes
1×8Membranes
ab169815
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生理活性物質

製品名

解説

製品番号

MMP-9 inhibitorMMP-9 inhibitor. Role in tumor cell migration, invasion and angiogenesisab142180
MMP-2/MMP-9 Inhibitor IMatrix metalloproteinase inhibitor of MMP-2/MMP-9. Synergizes with TNF-α to induce apoptosis in cancer cells. Active in vitro.ab145190
beta-ElemeneAnticancer agent. Induces G2M cell cycle arrest and apoptosis. Induces caspase-3, -7 and -9 activities. Decreases Bcl-2 expression. Induces mitochondrial release of cytochrome c. Inhibits microtubule polymerization. Downregulates uPA, uPAR, MMP-2, and MMP-9 expression. Shows antiproliferative effects. Shows antitumor effects in vivo. ab145171
Batimastat (BB-94)Potent, broad-spectrum MMP inhibitor (IC50 values are 3 (MMP-1), 4 (MMP-2), 4 (MMP-9), 6 (MMP-7), 20 nM (MMP-3)). Anticancer activity in vivo.ab142087
CL-82198Selective MMP-13 inhibitor (IC50 = 3.2 μM). Displays no activity against MMP-1, MMP-9 or TACE. Active in vivo.ab141576
生理活性物質一覧

ライゼート

製品名

製品番号

MMP1 293T Transfected Lysate - (positive control)ab94053
MMP10 293T Transfected Lysate - (positive control)ab94294

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Cancer
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MMP9

MMP-9 発現誘導プロトール

ゼラチナーゼ活性の測定

APC ~ 注目ターゲットのおすすめ製品


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APC Rat, HuICC, IHC-P, IP, WB52 ab40778
APC (HRP) HuIHC-P ab193785

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Abreview
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APCRb-PHu, Ms, XlICC/IF, IHC-P, IP, WB106 ab15270
APCMs-MHu, Ms, Rat, MkFlow Cyt, ICC/IF, IHC-Fr, IHC-FrFl, IHC-P152 ab16794
APC (pS2054)Rb-PHuELISA, IHC-P1 ab59421
APC (HRP)Ms-M HuIHC-Fr, IP, WB ab187799
抗体一覧

APC について

Function
機能
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Tissue specificity
組織特異性
Expressed in a variety of tissues.
Involvement in disease
関連疾患
Defects in APC are a cause of familial adenomatous polyposis (FAP) [MIM:175100]; which includes also Gardner syndrome (GS). FAP and GS contribute to tumor development in patients with uninherited forms of colorectal cancer. FAP is characterized by adenomatous polyps of the colon and rectum, but also of upper gastrointestinal tract (ampullary, duodenal and gastric adenomas). This is a viciously premalignant disease with one or more polyps progressing through dysplasia to malignancy in untreated gene carriers with a median age at diagnosis of 40 years. Defects in APC are a cause of hereditary desmoid disease (HDD) [MIM:135290]; also known as familial infiltrative fibromatosis (FIF). HDD is an autosomal dominant trait with 100% penetrance and possible variable expression among affected relatives. HDD patients show multifocal fibromatosis of the paraspinal muscles, breast, occiput, arms, lower ribs, abdominal wall, and mesentery. Desmoid tumors appears also as a complication of familial adenomatous polyposis. Defects in APC are a cause of medulloblastoma (MDB) [MIM:155255]. MDB is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. Although the majority of medulloblastomas occur sporadically, some manifest within familial cancer syndromes such as Turcot syndrome and basal cell nevus syndrome (Gorlin syndrome). Defects in APC are a cause of mismatch repair cancer syndrome (MMRCS) [MIM:276300]; also known as Turcot syndrome or brain tumor-polyposis syndrome 1 (BTPS1). MMRCS is an autosomal dominant disorder characterized by malignant tumors of the brain associated with multiple colorectal adenomas. Skin features include sebaceous cysts, hyperpigmented and cafe au lait spots. Defects in APC are a cause of gastric cancer (GASC) [MIM:613659]; also called gastric cancer intestinal or stomach cancer. Gastric cancer is a malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. Defects in APC are a cause of hepatocellular carcinoma (HCC) [MIM:114550]. This defect includes also the disease entity termed hepatoblastoma.
Sequence similarities
配列類似性
  • Belongs to the adenomatous polyposis coli (APC) family.
  • Contains 7 ARM repeats.
Post-translational modifications
翻訳後修飾
Phosphorylated by GSK3B. Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is facilitated by Axin. Deubiquitinated by ZRANB1/TRABID.
Cellular localization
細胞内局在性
Cell junction > adherens junction. Cytoplasm > cytoskeleton. Cell projection > lamellipodium. Cell projection > ruffle membrane. Cytoplasm. Cell membrane. Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.

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Cancer
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ErbB

バイオ関連ニュース17.8.4

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