製品の概要

  • 製品名Anti-BIN1 antibody
    BIN1 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to BIN1
  • 特異性ab106937 is expected to recognize isoform 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10 (NP_647593.1, NP_647594.1, NP_647595.1, NP_647596.1, NP_647597.1, NP_647598.1, NP_647599.1, NP_004296.1, NP_647600.1, NP_647601.1).
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Cow, Pig
  • 免疫原

    Synthetic peptide:

    C-SDNAPAKGNKSPS

    , corresponding to internal sequence amino acids 286-298 of Human BIN1 (NP_647593.1)

  • ポジティブ・コントロール
    • Human skeletal muscle lysates

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab106937 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 70, 60 kDa (predicted molecular weight: 65 kDa).

ターゲット情報

  • 機能May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
  • 組織特異性Ubiquitous. Highest expression in the brain and muscle. Isoform IIA is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier. Isoform BIN1 is widely expressed with highest expression in skeletal muscle.
  • 関連疾患Defects in BIN1 are the cause of centronuclear myopathy autosomal recessive (ARCNM) [MIM:255200]; also known as autosomal recessive myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
  • 配列類似性Contains 1 BAR domain.
    Contains 1 SH3 domain.
  • 翻訳後修飾Phosphorylated by protein kinase C.
  • 細胞内局在Cytoplasm and Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AMPH 2 antibody
    • AMPH2 antibody
    • Amphiphysin 2 antibody
    • Amphiphysin II antibody
    • Amphiphysin like protein antibody
    • amphiphysin-like antibody
    • Amphiphysin-like protein antibody
    • AMPHL antibody
    • Bin1 antibody
    • BIN1_HUMAN antibody
    • Box Dependant MYC Interacting Protein 1 antibody
    • Box-dependent myc-interacting protein 1 antibody
    • Bridging integrator 1 antibody
    • DKFZp547F068 antibody
    • MGC10367 antibody
    • MGC105358 antibody
    • Myc box dependent interacting protein 1 antibody
    • Myc box-dependent-interacting protein 1 antibody
    • SH3P9 antibody
    see all

Anti-BIN1 antibody 画像

  • Anti-BIN1 antibody (ab106937) at 0.1 µg/ml + Human skeletal muscle lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 65 kDa
    Observed band size : 60 + 70 kDa (why is the actual band size different from the predicted?)


    Exposure time : 1 hour

Anti-BIN1 antibody (ab106937) 使用論文

ab106937 has not yet been referenced specifically in any publications.

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