製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Bikunin
  • 特異性
    Ab21242 recognises bikunin.
  • アプリケーション
    適用あり: WB, ELISA, IHC-Fr, IHC-Pmore details
  • 種交差性
    交差種: Rat
  • 免疫原

    Full length native protein (purified): Rat bikunin

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab21242 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/2000. Predicted molecular weight: 39 kDa.
ELISA 1/2000.
IHC-Fr Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 機能
    Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.
    Trypstatin is a trypsin inhibitor.
  • 組織特異性
    Expressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha-trypsin inhibitor is present in plasma and urine.
  • 配列類似性
    In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
    Contains 2 BPTI/Kunitz inhibitor domains.
  • 翻訳後修飾
    The precursor is proteolytically processed into separately functioning proteins.
    3-hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with Cys-53, Lys-111, Lys-137, and Lys-149 to form heterogeneous polycyclic chromophores including hydroxanthommatin. The reaction by alpha-1-microglobulin is autocatalytic; the human protein forms chromophore even when expressed in insect and bacterial cells. The chromophore can react with accessible cysteines forming non-reducible thioether cross-links with other molecules of alpha-1-microglobulin or with other proteins such as Ig alpha-1 chain C region 'Cys-352'.
    Heavy chains are interlinked with bikunin via a chondroitin 4-sulfate bridge to the their C-terminal aspartate.
    Addition of glycosaminoglycan chondroitin sulfate, allows cross-linking between the different components.
  • 細胞内局在
    Secreted.
  • Information by UniProt
  • 参照データベース
  • 製品の状態
    Bikunin, the light chain of the proteinase inhibitors inter-alpha-inhibitor and pre-alpha-inhibitor, is synthesized in the liver. Its biological function is unclear but it has been shown to inhibit proteases and to have additional activities in vitro. Bikunin is translated as a precursor protein from the same mRNA as alpha 1-microglobulin. This cosynthesis is unique compared to other proproteins since they have no known functional connection.
  • 別名
    • Alpha 1 microglobulin/bikunin precursor antibody
    • Alpha-1 microglycoprotein antibody
    • AMBP antibody
    • AMBP_HUMAN antibody
    • Bikunin antibody
    • Complex-forming glycoprotein heterogeneous in charge antibody
    • EDC1 antibody
    • Growth inhibiting protein 19 antibody
    • HI 30 antibody
    • HI-30 antibody
    • HI30 antibody
    • IATIL antibody
    • Inter alpha trypsin inhibitor light chain antibody
    • ITI antibody
    • ITI LC antibody
    • ITI-LC antibody
    • ITILC antibody
    • Protein HC antibody
    • Trypstatin antibody
    • Uronic-acid-rich protein antibody
    • UTI antibody
    see all

参考文献

ab21242 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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