Anti-BHLHA15 抗体 [6E8/A12/C11P1] (ab110919)

製品の概要

• 製品名
  Anti-BHLHA15 antibody [6E8/A12/C11P1]
  BHLHA15 一次抗体 製品一覧
• 製品の詳細
  Mouse monoclonal [6E8/A12/C11P1] to BHLHA15
• アプリケーション
  適用あり: WB, IHC-P, IHC-Frmore details
• 種交差性
  交差種: Mouse, Human
  
• 免疫原

  Synthetic peptide, corresponding to C terminal amino acids 175-197 of Mouse BHLHA15.

• ポジティブ･コントロール
  • Mouse pancreas tissue.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファー
  Preservative: 0.05% Sodium azide
  Constituents: 99.85% PBS, 0.1% BSA
• Concentration information loading...
• 精製度
  Protein A purified
• ポリ/モノ
  モノクローナル
• クローン名
  6E8/A12/C11P1
• アイソタイプ
  IgG
• 研究分野
  • Epigenetics and Nuclear Signaling
  • Transcription
  • Domain Families
  • HLH / Leucine Zipper
  • HLH

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Transcription Factors

  • Epigenetics and Nuclear Signaling
  • Chromatin Binding Proteins
  • DNA / RNA binding

関連製品

• Compatible Secondaries
  • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
  • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
• Positive Controls
  • Pancreas (mouse) normal tissue slides (ab4610)

アプリケーション

ターゲット情報

• 機能
  Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3'.
• 組織特異性
  Expressed in brain, liver, spleen and skeletal muscle.
• 配列類似性
  Contains 1 basic helix-loop-helix (bHLH) domain.
• ドメイン
  Lacks a classic transcription activation domain and instead possesses an N-terminal region capable of inhibiting heterologous activators.
• 細胞内局在
  Nucleus.

• Target information above from: UniProt accession Q7RTS1 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 168620 Human
  • Entrez Gene: 17341 Mouse
  • Omim: 608606 Human
  • SwissProt: Q7RTS1 Human
  • SwissProt: Q9QYC3 Mouse
  • Unigene: 674510 Human
  • Unigene: 386767 Mouse
• 別名
  • Basic helix loop helix domain containing class B 8 antibody
  • Basic helix loop helix family member a15 antibody
  • BHA15_HUMAN antibody

  • Bhlha15 antibody
  • bHLHB8 antibody
  • Class A basic helix-loop-helix protein 15 antibody
  • Class B basic helix-loop-helix protein 8 antibody
  • Class II bHLH protein MIST1 antibody
  • intestine and stomach expression 1 antibody
  • MIST 1 antibody
  • MIST-1 antibody
  • MIST1 antibody
  • Muscle antibody
  • Muscle intestine and stomach expression 1 antibody
  • protein MIST1 antibody

  see all

プロトコール

• Immunohistochemistry protocols
• Western blot protocols