製品の概要

  • 製品名
    Anti-beta Synuclein antibody
    beta Synuclein 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to beta Synuclein
  • 特異性
    This antibody is specific for beta synuclein and does not cross react with alpha or gamma synuclein
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rat
  • 免疫原

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive).

  • ポジティブ・コントロール
    • Brain. Stains neuronal cytosol and presynaptic terminals.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab15532 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/100.

ターゲット情報

  • 機能
    Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
  • 組織特異性
    Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
  • 配列類似性
    Belongs to the synuclein family.
  • 翻訳後修飾
    Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
  • 細胞内局在
    Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 14 kDa brain-specific protein antibody
    • Beta-synuclein antibody
    • Phosphoneuroprotein 14 antibody
    • PNP14 antibody
    • Sncb antibody
    • Synuclein beta antibody
    • SYUB_HUMAN antibody
    see all

画像

  • ab15532 staining beta Synuclein in human brain by Immunohistochemistry (FFPE-sections).

プロトコール

参考文献

ab15532 has not yet been referenced specifically in any publications.

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